Influence of intraperitoneal application of taurolidine on the perioperative metastases, tumor recurrence and survival rate after surgical resection of colorectal cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN43522674

Enrollment

2000

Registered

2005-05-05

Start date

2005-06-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer Cancer Colorectal cancer

Interventions

2000 patients with colorectal cancer will be randomised to receive either taurolidine or NaCl solution during resection. Tumor recurrence, metastases and survival rates will be investigated up to 5 ye

Eligibility

Inclusion criteria

Inclusion criteria: Patients with colorectal cancer and curative resection, age over 18 years, American Society of Anesthesiologists (ASA) classification <IV.

Exclusion criteria

Exclusion criteria: 1. Ileus 2. Peritoneal carcinomatosis 3. Intraperitoneal abscess formation 4. Intestinal perforation 5. Peritonitis 6. Sepsis 7. Organ falure 8. ASA classification IV 9. R1 or R2 resection

Design outcomes

Primary

Measure	Time frame
Time to local and distant tumor relapse (disease free survival).	—

Secondary

Measure	Time frame
Global survival time.	—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026