Best first line treatment options for unexplained infertility Pregnancy and Childbirth Infertility
Conditions
Interventions
Randomisation will be performed by an independent worker in blocks of 10 and distributed in individual consecutively numbered opaque envelopes. Participants will be randomised into two groups:
Group
Sponsors
Homerton University Hospital (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Couples with female partner's age between 23- 37 years 2. Diagnosed with unexplained infertility at the time of first treatment 3. Inability to conceive following a minimum of one year of unprotected intercourse 4. In the presence of normal semen analysis, proof of regular ovulatory cycles with a day 3 follicle stimulating hormone (FSH)<10IU/L 5. Two patent tubes and a normal uterine cavity on hysterosalpingography (HSG)
Exclusion criteria
Exclusion criteria: 1. Female partner aged 37 years or more 2. People with physical disability or psychosexual problems who find difficulty in achieving vaginal intercourse 3. Couples in a same sex relationship (as these do not fall into the definition of unexplained infertility) 4. Couples where the male/female is HIV positive, as they would need specific consideration to methods of conception 5. Couples who have had no previous IUI or IVF treatment for infertility
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Singleton live birth rate is assessed using medical record review | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Clinical pregnancy rate is assessed using medical record review 2. Multiple pregnancy rates is assessed using medical record review | — |
Countries
United Kingdom
Outcome results
None listed