Maximising clinical applicability of non-invasive methods for optimisation of cardiac pacemakers and effect of optimisation on cardiac efficiency

Maximising clinical applicability of non-invasive methods for optimisation of cardiac pacemakers and effect of optimisation on cardiac efficiency: a non-randomised interventional validation of investigational process trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN43384180

Enrollment

Registered

2010-04-29

Start date

2009-01-01

Completion date

Unknown

Last updated

2017-06-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Diabetes Research Network

Interventions

Optimisation of CRT devices: 1. Patients with existing devices are invited to attend for non-invasive haemodynamic optimisation 2. Patients are temporarily paced biventricularly at high heart rate and

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Chronic systolic heart failure and a biventricular device 2. In sinus rhythm (or atrially paced at rest) 3. Free of frequent ectopy 4. No aortic stenosis 5. Either sex, aged 40 - 90 years

Exclusion criteria

Exclusion criteria: 1. Severe lung disease 2. Any condition that would preclude participants from lying comfortably on a couch for the duration of the study 3. No admissions, other than the admission related to the procedure for the invasive substudy in the prior month 4. No changes to medications (other than diuretic dose) in the prior month

Design outcomes

Primary

Measure	Time frame
1. Acute improvement in systolic blood pressure 2. Cardiac efficiency Timepoints: End of first year and end of second year	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026