Endometrial cancer, endometrial hyperplasia, polyps and normal endometrium Cancer
Conditions
Interventions
The project will involve a comprehensive analysis of endometrial hyperplasia (EH) against endometrial cancer (EC), polyps and normal samples, and compare findings with diet and lifestyle parameters as
Sponsors
Portsmouth Hospitals NHS Trust
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women seen in Post Menopausal Clinic at Queen Alexandra Hospital 2. Ability to consent 3. Aged 40 years or over 4. Women with endometrial polyps 5. Women with prolapse awaiting surgery 6. Normal up to date smear 7. Normal endometrial sampling at screening 8. Not on prior endocrine treatment 9. No other/second cancer in the present or past;Inclusion criteria: 1. Women seen in Post Menopausal Clinic at Queen Alexandra Hospital 2. Ability to consent 3. Aged 40 years or over 4. Women with endometrial polyps 5. Women with prolapse awaiting surgery 6. Normal up to date smear 7. Normal endometrial sampling at screening 8. Not on prior endocrine treatment 9. No other/second cancer in the present or past
Exclusion criteria
Exclusion criteria: Exclusion criteria as of 21/04/2017: 1. Previous hysterectomy 2. Breast cancer and breast cancer therapy 3. Taking systemic hormone replacement therapy or endocrine treatment Original exclusion criteria: 1. Previous hysterectomy 2. Breast cancer and breast cancer therapy 3. Congenital/acquired uterine anomalies 4. Pelvic inflammatory disease, previous and active 5. Immunodeficiency or any chronic disease 6. Taking systemic hormone replacement therapy or endocrine treatment;Exclusion criteria: Exclusion criteria as of 21/04/2017: 1. Previous hysterectomy 2. Breast cancer and breast cancer therapy 3. Taking systemic hormone replacement therapy or endocrine treatment Original exclusion criteria: 1. Previous hysterectomy 2. Breast cancer and breast cancer therapy 3. Congenital/acquired uterine anomalies 4. Pelvic inflammatory disease, previous and active 5. Immunodeficiency or any chronic disease 6. Taking systemic hormone replacement therapy or endocrine treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lifestyle and diet assessment score, biochemical data, histological grade and genetic data will form a multivariate model. Generated data will be used for statistical modeling, where tests will be performed to determine differences between study cases. In order to determine which combination of tested variables best predicts EC, a stepwise discriminant analysis will be used.;Lifestyle and diet assessment score, biochemical data, histological grade and genetic data will form a multivariate model. Generated data will be used for statistical modeling, where tests will be performed to determine differences between study cases. In order to determine which combination of tested variables best predicts EC, a stepwise discriminant analysis will be used. | — |
Secondary
| Measure | Time frame |
|---|---|
| Detection of differences in biochemical, histological and genetic results between studied conditions.;Detection of differences in biochemical, histological and genetic results between studied conditions. | — |
Countries
United Kingdom
Contacts
Public ContactIolia;Iolia Akaev;Akaev
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Outcome results
None listed