A study assessing the usefulness of measuring platelet function after cardiac surgery

The role of point-of-care assessment of platelet function in predicting postoperative bleeding and transfusion requirements after coronary artery bypass grafting (CABG)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN43298975

Enrollment

Registered

2014-01-23

Start date

2011-11-16

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease / Coronary Artery Bypass Graft / Antiplatelet medications Circulatory System Atherosclerotic heart disease

Interventions

Current interventions as of 01/04/2014: Group A (n=42) will include patients who were on anti-platelet drugs until the day of surgery. Group B (n=42) will include patients who stopped anti-platelet dr

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Male and female patients aged 18 years and over 2. Patient who can give informed consent 3. Patients undergoing first time coronary artery bypass graft (CABG) using cardiopulmonary bypass

Exclusion criteria

Exclusion criteria: 1. Patients who are unable to consent 2. Patients less than 18 years old 3. Severe liver or renal dysfunction (Altered Liver Function Test, Creatinine >200) 4. Patients who are already part of another study 5. Patient with known bleeding diathesis

Design outcomes

Primary

Measure	Time frame
Current primary outcome measures as of 01/04/2014: The primary endpoint was to correlate excessive post-operative bleeding defined as blood loss in excess of 2.5 ml/kg/hr in the immediate 3 hours, with the presence of platelet dysfunction as assessed by Multiplate® and TEG. Previous primary outcome measures: The primary endpoint is to correlate excessive postoperative bleeding defined as a blood loss of 2.5 ml/kg/hr in the immediate 3 hours and the total bleeding within the first 8 hours post-surgery, with the presence of platelet dysfunction as measured by the Multiplate®.	—

Measure

Time frame

Current primary outcome measures as of 01/04/2014: The primary endpoint was to correlate excessive post-operative bleeding defined as blood loss in excess of 2.5 ml/kg/hr in the immediate 3 hours, with the presence of platelet dysfunction as assessed by Multiplate® and TEG. Previous primary outcome measures: The primary endpoint is to correlate excessive postoperative bleeding defined as a blood loss of 2.5 ml/kg/hr in the immediate 3 hours and the total bleeding within the first 8 hours post-surgery, with the presence of platelet dysfunction as measured by the Multiplate®.

—

Secondary

Measure	Time frame
Current secondary outcome measures as of 01/04/2014: 1. Transfusion requirements for blood and blood products 2. Overall blood loss within 8 hours of surgery 3. Postoperative complications 4. Intensive care unit (ICU) length of stay 5. Hospital length of stay Previous secondary outcome measures: 1. Transfusion requirements for blood and blood products 2. Comparison of Multiplate® and TEG 3. Postoperative complications 4. ICU length of stay 5. Hospital length of stay	—

Measure

Time frame

Current secondary outcome measures as of 01/04/2014: 1. Transfusion requirements for blood and blood products 2. Overall blood loss within 8 hours of surgery 3. Postoperative complications 4. Intensive care unit (ICU) length of stay 5. Hospital length of stay Previous secondary outcome measures: 1. Transfusion requirements for blood and blood products 2. Comparison of Multiplate® and TEG 3. Postoperative complications 4. ICU length of stay 5. Hospital length of stay

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026