Prevention of hypertensive disorders of pregnancy, in particular, pre-eclampsia Pregnancy and Childbirth
Conditions
Interventions
This was a single center interventional, open labelled randomized controlled trial. The study was conducted at a regional hospital in South Africa to evaluate the effectiveness of low-dose aspirin (LD
Sponsors
University of KwaZulu-Natal
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Pregnant women that is 18 years and older 2. Pregnant women and women with one or more risk factors for hypertensive disorders of pregnancy, such as a previous history of unexplained pregnancy loss, 3. Previous history or family history of hypertensive disorders,
Exclusion criteria
Exclusion criteria: 1. Women on aspirin or other antiplatelet agents 2. Women with multiple pregnancies 3. Women with fetal abnormalities, diabetes, hypertension, anemia, or other chronic diseases. 4. women with contraindications to aspirin use 5. Women who decline entry to the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypertensive disorders of pregnancy including pre-eclampsia (both early and late) and gestational hypertension (defined as a systolic blood pressure (SBP) =140 mm Hg and/or diastolic blood pressure (DBP) =90 mm Hg after 20 weeks of gestation in a woman who was at baseline normotensive) measured using a sphygmomanometer | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Gestational age measured at delivery 2. Baby weight measured in kg at birth 3. Infant outcome (dead or alive) during antenatal period | — |
Countries
South Africa
Contacts
Public ContactPrincess Zinhle;Vinogrin Mkhize;Dorsamy
;
Outcome results
None listed