Early Alzheimer's disease Nervous System Diseases Alzheimer's disease
Conditions
Interventions
Subjects will be randomly allocated to either a cognitive training group or control group. The cognitive training group will undergo 18 days of training over 6 weeks for approximately 45 minutes/day.
Sponsors
Institute of Psychiatry (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged greater than 60 years, either sex 2. Diagnosis of probable Alzheimer's disease according to National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria 3. Mini-Mental State Examination (MMSE) score greater than 23/30 4. All subjects will be required to provide informed consent to participate in the study
Exclusion criteria
Exclusion criteria: 1. Co-existent neurological or psychiatric disease 2. Substance misuse 3. Significant auditory or visual impairment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Scores on verbal working memory task 2. Cerebral blood flow in the prefrontal and parietal cortices as measured using fMRI Measured at baseline and after 8 weeks (following the 6 week cognitive training intervention). | — |
Secondary
| Measure | Time frame |
|---|---|
| Scores on: 1. Spatial working memory task 2. Sustained attention, reasoning and episodic memory tasks 3. Artificial grammar task 4. Instrumental activities of daily living (ADL) task Measured at baseline and after 8 weeks (following the 6 week cognitive training intervention). | — |
Countries
United Kingdom
Outcome results
None listed