Bacterial meningitis Nervous System Diseases Bacterial meningitis
Conditions
Interventions
Double blind randomised controlled trial. The intervention will be dexamethasone.
Sponsors
University of Oxford (UK)
Eligibility
Inclusion criteria
Inclusion criteria: 1. The treating physician believes the diagnosis to be BM 2. History less than ten days (unless still Serebrospinal Fluid [CSF] evidence of bacteria) 3. CSF white cell count more than 50 with more than 50% neutrophils 4. CSF glucose less than 50% of blood glucose
Exclusion criteria
Exclusion criteria: 1. Chest X-Ray (CXR) shows evidence of possible Tuberculosis (TB) 2. History is longer than ten days 3. History of hypersensitivity to beta-lactam antibiotics 4. Known severe liver or renal impairment 5. Patients in whom the physician believes corticosteroids are contraindicated e.g. uncontrolled diabetes, gastro-intestinal bleeding etc. 6. Pre-existing severe neurological disability 7. Pregnancy within the first trimester
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures | — |
Countries
Viet Nam
Outcome results
None listed