High-normal blood pressure and/or impaired glucose regulation. Circulatory System Hypertension
Conditions
Interventions
Subjects were randomly assigned to either the SNAC intervention group or the usual care group.
The SNAC intervention group received the SNAC lifestyle intervention that combined the STEP test and exe
Sponsors
Lawson Health Research Institute (Canada)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Men and women aged 40 - 85 years who are able to provide informed consent 2. Presence of high-normal blood pressure, impaired fasting glucose, impaired glucose tolerance, or all of them
Exclusion criteria
Exclusion criteria: 1. Unstable cardiovascular or metabolic disease 2. Previous diagnosis of hypertension or type 2 diabetes 3. Myocardial infarction, coronary artery bypass, or cerebrovascular ischaemia/stroke (including Transient Ischaemic Attack [TIA]) within 3 months prior to study 4. History of alcoholism, drug abuse, or other emotional, cognitive or psychiatric problems that are likely to limit compliance to the study 5. Pacemaker 6. Already enrolled in a clinical research trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvements in exercise capacity, left ventricular diastolic function (E/A ratio), and brachial artery endothelial function, measured at V1 - V5 (see interventions). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Caloric profile and anthropometrics, measured at V1 - V5 (see interventions) 2. Resting blood pressure and 24-hour ambulatory blood pressure, measured at V1 - V5 3. Blood chemistries (glucose, lipids, catecholamines, HbA1c, etc), measured at V1 - V5 4. Muscle sympathetic nerve activity, measured at V1 - V5 5. Geometry and elastic properties of the carotid artery, and geometry of left ventricle, measured at V1 - V5 | — |
Countries
Canada
Outcome results
None listed