Can serial changes in diaphragm function during the spontaneous breathing trial predict the weaning outcome?

The predictive value of serial changes in diaphragm function during the spontaneous breathing trial for weaning outcome

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN42917473

Enrollment

Registered

2016-11-03

Start date

2016-11-01

Completion date

Unknown

Last updated

2020-12-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mechanical ventilation Not Applicable

Interventions

The tube compensation mode (TC) is used to perform the spontaneous breathing trial (SBT) with the compensation ratio at 85%. The patients undergo SBT for 2 hours in a semi-recumbent position. If the p

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. All patients in the ICU who are mechanically ventilated for more than 48 hours through an endotracheal tube 2. Absence of fever 3. Alert and cooperative 4. Hemodynamically stabile without vasopressors 5. Improved respiratory function with FiO2 200 and respiratory rate <30 breaths per minute 6. Aged 18 or over

Exclusion criteria

Exclusion criteria: 1. History of diaphragm paralysis 2. Cervical spine injury 3. Neuromuscular diseases 4. A current thoracostomy 5. Pneumothorax 6. Pneumomediastinum

Design outcomes

Primary

Measure	Time frame
Successful weaning, defined as spontaneous breathing (SB) for >48 hours following extubation without any level of ventilator support. A failed weaning was defined as either SBT failure or the inability to maintain SB for at least 48 hours after extubation.	—

Countries

China

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 26, 2026