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Brain network malleability by computerised cognitive training in attention deficit hyperactivity disorder

A randomised controlled trial to examine the effects of computerised working memory training on brain activity and structural and functional connectivity in adults with attention deficit hyperactivity disorder

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN42801302
Enrollment
60
Registered
2024-05-09
Start date
2015-08-01
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Attention deficit hyperactivity disorder Mental and Behavioural Disorders

Interventions

After a pretest including neuropsychological assignment, cognitive tasks, and magnetic resonance imaging, the participants were assigned to an experimental group (performing dual n-back working memory

Sponsors

Åbo Akademi University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Age between 18 and 63 years 2. Diagnosed with attention deficit hyperactivity disorder according to DSM-IV by a specialised doctor 3. Excellent competency in Finnish 4. Sufficient vision and hearing

Exclusion criteria

Exclusion criteria: 1. History of brain damage 2. Other severe neurological or psychiatric disorders apart from ADHD, including substance abuse or other addictions 3. IQ lower than 70 assessed by the Wechsler Adult Intelligence Scale III 4. Magnetic resonance imaging contraindications

Design outcomes

Primary

MeasureTime frame
Blood oxygen level dependent (BOLD) signal in the brain measured by functional magnetic resonance imaging during the pretest (within few weeks before the cognitive training) and the posttest (within few weeks after the cognitive training). Due to the study’s experimental design, BOLD signal is assessed in different conditions (during working memory task, rest, and movie watching) and can be analysed in several ways, including regional activity and their temporal correlations.

Secondary

MeasureTime frame
White matter properties of the brain measured by diffusion-weighted magnetic resonance imaging during the pretest (within a few weeks before the cognitive training) and the posttest (within a few weeks after the cognitive training). White matter properties can be analysed in several ways, including microstructure and tractography.

Countries

Finland

Contacts

Public ContactTuija Tolonen
tuija.tolonen@helsinki.fi

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026