Spontaneous coronary artery dissection Circulatory System
Conditions
Interventions
The study has two elements.
The first is an observational registry. Consenting patients allow access to their medical information and clinical imaging at the time and following their Spontaneous Coro
Sponsors
University of Leicester
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with angiographically proven SCAD (confirmed by the study team). 2. Healthy volunteers
Exclusion criteria
Exclusion criteria: Iatrogenic, atherosclerotic or traumatic dissections
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Presenting clinical data from index admission with Spontaneous Coronary Artery Dissection, review of patient notes and imaging, at baseline 2. Demographic, medical, obstetric, contraceptive and family history, review of patient notes, online (bespoke) questionnaires, patient interview, at time of registration 3. Coronary angiographic findings, patient imaging data, at baseline 4. MACCE, SCAD recurrence, pregnancy at follow-up, questionnaires clarified by patient interview if required, annually | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. CMR assessment of myocardial function and infarct size, either from scans conducted on clinical grounds or research scans arranged as part of the phenotyping study 2. MRA/CTA assessment of remote arteriopathies either from scans conducted on clinical grounds or research scans arranged as part of the phenotyping study 3. USS assessment of arteries including FMD, IMT, luminal dimensions arranged as part of the phenotyping study 4. Cardiopulmonary exercise testing arranged as part of the phenotyping study 5. Ambulatory ECG monitoring conducted either on clinical grounds or arranged as part of the phenotyping study 6. Blood sampling for biomarkers and genetic studies 7. Skin biopsies for fibroblast culture for laboratory assays | — |
Countries
England, United Kingdom
Outcome results
None listed