Breast cancer Cancer Malignant neoplasm of the breast
Conditions
Interventions
The trial is anticipated to have an active recruitment period of 14 months. Patients will receive MRI scans at baseline (pre-commencement of chemotherapy), 4 - 7 days after commencement of their first
Sponsors
Hull and East Yorkshire NHS Trust (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Provide written informed consent 2. Female 3. Aged 18 years or over 4. Newly diagnosed, histologically proven breast cancer (TNM stage T2- T4B, N0-3C, and M0) 5. Undergone both x-ray mammography and breast ultrasound scanning during the current treatment episode 6. Scheduled for neo-adjuvant chemotherapy
Exclusion criteria
Exclusion criteria: 1. Are medically unstable 2. Previously undergone chemotherapy 3. Have had surgery or radiotherapy for cancer in the ipsilateral breast 4. Have had surgery to the ipsilateral breast within the previous 4 months for benign breast disease 5. Have a history of serious breast trauma within the last 3 months 6. Are pregnant or breast feeding 7. Have renal failure 8. Fail the normal safety requirements of MR, particularly pacemakers and cardiac defibrillators 9. Are known to have had an allergic reaction associated with previous administration of a paramagnetic contrast agent 10. Have a known contraindication to MR scanning 11. Have a disability preventing MR scanning in the prone position 12. Have body habitus incompatible with MR system entry
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The technical feasibility of using MR imaging in a multicentre setting using the most commonly available MR systems (i.e. is the trial able to scan patients to a specific protocol, using different types of MRI machine) 2. How reliably the imaging data can be analysed in a centralised, semi-automated, manner (i.e. can MRI data be reliably transferred from different centres and analysed using software based in the Centre for MR Investigations at the University of Hull) | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures | — |
Countries
England, United Kingdom
Outcome results
None listed