A prospective , double blind, randomised controlled trial evaluating the effects of mitomycin C on postoperative healing following endoscopic sinus surgery (ESS) to the frontonasal recess.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN42522811

Enrollment

Registered

2005-09-30

Start date

2005-01-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery: Endoscopic sinus surgery (ESS) Surgery Endoscopic sinus surgery (ESS)

Interventions

Patients undergoing ESS to the frontonasal recess for chronic rhinosinusitis are randomly allocated to receive either MMC or placebo solution applied to the frontonasal recess.

Eligibility

Inclusion criteria

Inclusion criteria: Not provided at time of registration

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

Measure	Time frame
1. Patency of the frontonasal recess. 2. Study of the formation of adhesions and rate of restenosis post operatively.	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026