Research demonstration projects in mental health and homelessness

Multi-site pragmatic randomised controlled field trial of Housing First versus treatment as usual in mental health and homelessness

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN42520374

Enrollment

2225

Registered

2009-08-18

Start date

2009-10-01

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Homelessness and serious mental illness Mental and Behavioural Disorders Mental disorder, not otherwise specified

Linh D. Luong, Cília Mejía-Lancheros, Fiona G. Kouyoumdjian, James Lachaud, Stephen W. Hwang

The Canadian Journal of Psychiatry2025-09-032 citations

10.1177/07067437251372188

Housing and Support Intervention and Mortality Among Homeless Adults With Mental Illnesses

James Lachaud, Rosane Nisenbaum, Cília Mejía-Lancheros, Éric Latimer, Tim Aubry et al. (14 authors)

JAMA Network Open2025-07-31

10.1001/jamanetworkopen.2025.24302

Women experiencing homelessness and mental illness in a Housing First multi-site trial: Looking beyond housing to social outcomes and well-being

Patricia O’Campo, Rosane Nisenbaum, Anne G. Crocker, Tonia L. Nicholls, Faith Eiboff et al. (6 authors)

PLoS ONE2023-02-1015 citations

10.1371/journal.pone.0277074

Effect of a housing intervention on major cardiovascular events among homeless adults with mental illness

Samantha S. Liauw, Cília Mejía-Lancheros, James Lachaud, Patricia O’Campo, Vicky Stergiopoulos et al. (6 authors)

Journal of Social Distress and the Homeless2022-06-132 citations

10.1080/10530789.2022.2086670

The Effect of a Housing First Intervention on Acute Health Care Utilization among Homeless Adults with Mental Illness: Long-term Outcomes of the At Home/Chez-Soi Randomized Pragmatic Trial.

Lachaud J, Mejia-Lancheros C, Durbin A, Nisenbaum R, Wang R, O'Campo P, Stergiopoulos V, Hwang SW.

2021-06-2816 citations

10.1007/s11524-021-00550-1

Severe Psychopathology and Substance Use Disorder Modify the Association Between Housing Trajectories and Food Security Among Homeless Adults

James Lachaud, Cília Mejía-Lancheros, Michael Liu, Ri Wang, Rosane Nisenbaum et al. (8 authors)

Frontiers in Nutrition2021-05-122 citations

10.3389/fnut.2021.608811

Multi-trajectory group profiles of well-being and associated predictors among adults experiencing homelessness and mental illness: findings from the At Home/Chez Soi study, Toronto site.

Mejia-Lancheros C, Lachaud J, Aubry T, Wiens K, O'Campo P, Stergiopoulos V, Hwang SW.

2021-04-178 citations

10.1007/s00127-021-02093-x

Associations of resilience with quality of life levels in adults experiencing homelessness and mental illness: a longitudinal study

Cília Mejía-Lancheros, Julia Woodhall‐Melnik, Ri Wang, Stephen W. Hwang, Vicky Stergiopoulos et al. (6 authors)

Health and Quality of Life Outcomes2021-03-0425 citations

10.1186/s12955-021-01713-z

The Long-Term Effects of a Housing First Intervention on Primary Care and Non-Primary Care Physician Visits Among Homeless Adults with Mental Illness: A 7-Year RCT Follow-Up

Cília Mejía-Lancheros, James Lachaud, Matthew J. To, Patsy Lee, Rosane Nisenbaum et al. (8 authors)

Journal of Primary Care & Community Health2021-01-014 citations

10.1177/21501327211027102

Effect of Housing First on violence-related traumatic brain injury in adults with experiences of homelessness and mental illness: findings from the At Home/Chez Soi randomised trial, Toronto site

Cília Mejía-Lancheros, James Lachaud, Vicky Stergiopoulos, Flora I. Matheson, Rosane Nisenbaum et al. (7 authors)

BMJ Open2020-12-0124 citations

10.1136/bmjopen-2020-038443

Patterns and predictors of high-cost users of the health system: a data linkage protocol to combine a cohort study and randomised controlled trial of adults with a history of homelessness

Kathryn Wiens, Laura C. Rosella, Paul Kurdyak, Stephen W. Hwang

BMJ Open2020-12-012 citations

10.1136/bmjopen-2020-039966

Effect of a Housing Intervention on Selected Cardiovascular Risk Factors Among Homeless Adults With Mental Illness: 24‐Month Follow‐Up of a Randomized Controlled Trial

Antony Chum, Ri Wang, Rosane Nisenbaum, Patricia O’Campo, Vicky Stergiopoulos et al. (6 authors)

Journal of the American Heart Association2020-09-2512 citations

10.1161/jaha.119.016896

Dental problems and chronic diseases in mentally ill homeless adults: a cross-sectional study.

Mejia-Lancheros C, Lachaud J, Nisenbaum R, Wang A, Stergiopoulos V, Hwang SW, O'Campo P.

2020-03-3010 citations

10.1186/s12889-020-08499-7

Long-term effects of rent supplements and mental health support services on housing and health outcomes of homeless adults with mental illness: extension study of the At Home/Chez Soi randomised controlled trial.

Stergiopoulos V, Mejia-Lancheros C, Nisenbaum R, Wang R, Lachaud J, O'Campo P, Hwang SW.

2019-10-0760 citations

10.1016/s2215-0366(19)30371-2

Gender differences among Indigenous Canadians experiencing homelessness and mental illness

Brittany Bingham, Akm Moniruzzaman, Michelle Patterson, Jitender Sareen, Jino Distasio et al. (7 authors)

BMC Psychology2019-08-2827 citations

10.1186/s40359-019-0331-y

A randomized controlled trial of the effectiveness of Housing First in a small Canadian City

Tim Aubry, Jimmy Bourque, Paula Goering, Susan Crouse, Scott Veldhuizen et al. (10 authors)

BMC Public Health2019-08-2245 citations

10.1186/s12889-019-7492-8

Cost-effectiveness of Housing First Intervention With Intensive Case Management Compared With Treatment as Usual for Homeless Adults With Mental Illness

Éric Latimer, Daniel Rabouin, Zhirong Cao, Angela Ly, Guido Powell et al. (13 authors)

JAMA Network Open2019-08-2151 citations

10.1001/jamanetworkopen.2019.9782

Convergent validity of the EQ-5D-3L in a randomized-controlled trial of the Housing First model.

Kozloff N, Pinto AD, Stergiopoulos V, Hwang SW, O'Campo P, Bayoumi AM.

2019-07-124 citations

10.1186/s12913-019-4310-z

Indigenous and non-Indigenous people experiencing homelessness and mental illness in two Canadian cities: A retrospective analysis and implications for culturally informed action

Brittany Bingham, Akm Moniruzzaman, Michelle Patterson, Jino Distasio, Jitender Sareen et al. (7 authors)

BMJ Open2019-04-0138 citations

10.1136/bmjopen-2018-024748

The effects of housing stability on service use among homeless adults with mental illness in a randomized controlled trial of housing first.

Kerman N, Sylvestre J, Aubry T, Distasio J.

2018-03-2029 citations

10.1186/s12913-018-3028-7

The effectiveness of a Housing First adaptation for ethnic minority groups: findings of a pragmatic randomized controlled trial.

Stergiopoulos V, Gozdzik A, Misir V, Skosireva A, Sarang A, Connelly J, Whisler A, McKenzie K.

2016-10-2129 citations

10.1186/s12889-016-3768-4

How did a Housing First intervention improve health and social outcomes among homeless adults with mental illness in Toronto? Two-year outcomes from a randomised trial

Patricia O’Campo, Vicky Stergiopoulos, Pam Nir, Matthew N. Levy, Vachan Misir et al. (10 authors)

BMJ Open2016-09-0189 citations

10.1136/bmjopen-2015-010581

Impact of a Housing First intervention on homeless Veterans with mental illness: a Canadian multisite randomized controlled trial

Jimmy Bourque, Linda VanTil, Caroline Gibbons, Stefanie Renée LeBlanc, Liette-Andrée Landry et al. (10 authors)

Journal of Military Veteran and Family Health2015-10-207 citations

10.3138/jmvfh.2985

The Impact of a 24 Month Housing First Intervention on Participants’ Body Mass Index and Waist Circumference: Results from the At Home / Chez Soi Toronto Site Randomized Controlled Trial

Julia Woodhall‐Melnik, Vachan Misir, Vered Kaufman‐Shriqui, Patricia O’Campo, Vicky Stergiopoulos et al. (6 authors)

PLoS ONE2015-09-2916 citations

10.1371/journal.pone.0137069

Effectiveness of Housing First with Intensive Case Management in an Ethnically Diverse Sample of Homeless Adults with Mental Illness: A Randomized Controlled Trial

Vicky Stergiopoulos, Agnes Gozdzik, Vachan Misir, Anna Skosireva, Jo Connelly et al. (10 authors)

PLoS ONE2015-07-15117 citations

10.1371/journal.pone.0130281

Effect of Scattered-Site Housing Using Rent Supplements and Intensive Case Management on Housing Stability Among Homeless Adults With Mental Illness

Vicky Stergiopoulos, Stephen W. Hwang, Agnes Gozdzik, Rosane Nisenbaum, Éric Latimer et al. (20 authors)

JAMA2015-03-03244 citations

10.1001/jama.2015.1163

Cardiovascular risk factors and 30-year cardiovascular risk in homeless adults with mental illness.

Gozdzik A, Salehi R, O'Campo P, Stergiopoulos V, Hwang SW.

2015-02-2322 citations

10.1186/s12889-015-1472-4

Differential experiences of discrimination among ethnoracially diverse persons experiencing mental illness and homelessness

Suzanne Zerger, Sarah Bacon, Simon Corneau, Anna Skosireva, Kwame McKenzie et al. (9 authors)

BMC Psychiatry2014-12-0160 citations

10.1186/s12888-014-0353-1

The impact of a Housing First randomized controlled trial on substance use problems among homeless individuals with mental illness.

Kirst M, Zerger S, Misir V, Hwang S, Stergiopoulos V.

2014-10-2848 citations

10.1016/j.drugalcdep.2014.10.019

Different faces of discrimination: perceived discrimination among homeless adults with mental illness in healthcare settings.

Skosireva A, O'Campo P, Zerger S, Chambers C, Gapka S, Stergiopoulos V.

2014-09-0791 citations

10.1186/1472-6963-14-376

Housing First: exploring participants' early support needs.

Stergiopoulos V, Gozdzik A, O'Campo P, Holtby AR, Jeyaratnam J, Tsemberis S.

2014-04-1343 citations

10.1186/1472-6963-14-167

Setting the stage for chronic health problems: cumulative childhood adversity among homeless adults with mental illness in Vancouver, British Columbia.

Patterson ML, Moniruzzaman A, Somers JM.

2014-04-1225 citations

10.1186/1471-2458-14-350

Missed opportunities: childhood learning disabilities as early indicators of risk among homeless adults with mental illness in Vancouver, British Columbia.

Patterson ML, Moniruzzaman A, Frankish CJ, Somers JM.

2012-11-229 citations

10.1136/bmjopen-2012-001586

The At Home/Chez Soi trial protocol: a pragmatic, multi-site, randomised controlled trial of a Housing First intervention for homeless individuals with mental illness in five Canadian cities.

Goering PN, Streiner DL, Adair C, Aubry T, Barker J, Distasio J, Hwang SW, Komaroff J, Latimer E, Somers J, Zabkiewicz DM.

2011-11-14171 citations

10.1136/bmjopen-2011-000323

Interventions

Treatment: provision of rent supplements and case management or assertive community treatment for the duration of the study Comparison: care as usual Duration of intervention: Data collection will be

Eligibility

Sex/Gender

All

Age

18 Years to 110 Years

Inclusion criteria

Inclusion criteria: 1. Legal adult status 2. Absolute homelessness or precariously housed 3. Presence of a serious mental disorder 4. Aged 18 years and older, either sex

Exclusion criteria

Exclusion criteria: Does not meet inclusion criteria

Design outcomes

Primary

Measure	Time frame
Housing stability, measured using the Tsemberis Residential Timeline Follow-back Inventory at 6, 12, 18 and 24 months	—

Secondary

Measure	Time frame
Quality of life, measured using the EQ-5D at 6, 12, 18 and 24 months	—

Countries

Canada

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 27, 2026