Polycystic ovary syndrome Nutritional, Metabolic, Endocrine Polycystic ovarian syndrome
Conditions
Interventions
The participants who fulfil the inclusion and exclusion criteria will be recruited for the study. All the participants will undergo two day procedures of either saline or intralipid infusion for 5 hou
Sponsors
Hull and East Yorkshire Hospitals NHS Trust (UK)
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-40 year premenopausal women 2. For lean participants BMI 18-25 kg/m2 3. For obese participants 26-40 kg/m2 4. The absence or presence of polycystic ovary syndrome (evidence of anovulation/oligomenorrhoea, clinical or biochemical hyperandrogenism, polycystic ovaries on ultrasound scanning which meets the PCOS diagnostic criteria of Rotterdam consensus statement) for controls and women with PCOS respectively
Exclusion criteria
Exclusion criteria: 1. Pregnancy/breastfeeding/trying to conceive 2. History of cardiovascular, renal, hepatic and thyroid disease 3. History of physical disability to exercise 4. History of diabetes mellitus 5. History of allergy to insulin/ soy oil, purified egg (intralipid) 6. Currently on oral anti-diabetic medication that improves insulin sensitivity such as metformin, weight reduction medication (orlistat, sibutramine) 7. Family history of sudden death 8. History of regular exercise three times a week for the last three months 9. Unwilling to be informed to their GP about their participation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VO2 max, HOMA-IR, rate of glucose disposal before or after intralipid, before or after exercise. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Lipid profiles, Blood pressure. BMI, HsCRP, endothelial markers (microparticles) 2. Platelet activation before and after intralipid infusion All parameters will be measured at baseline and at the end of the exercise program | — |
Countries
England, United Kingdom
Outcome results
None listed