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Effects of compound chamomile lidocaine gel after mandibular third molar surgeries

Effects of compound chamomile lidocaine gel after mandibular third molar surgeries: a double-blind randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN42225408
Enrollment
37
Registered
2026-06-19
Start date
2024-07-20
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgesic effect of compound chamomile lidocaine gel after third molar extraction Oral Health

Interventions

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Sponsors

Accademia di Belle Arti di Frosinone
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Age range: 18-50 years 2.no mouth opening restrictions, no cardiovascular or pulmonary diseases, normal liver and kidney function, no history of abnormal bleeding or coagulation disorders, or other contraindications to tooth extraction 3.Based on the combination of the Winter classification and the Pell & Gregory classification, we included mandibular third molars of classes IA, IB, IIA, IIB vertical, and IIA mesioangular impactions. All types of wisdom teeth surgeries were completed within 30 minutes by experienced doctors after evaluating imaging and oral examinations 4. The patient is in good overall health, with no systemic diseases (ASA I/II) 5. Voluntarily participates in the study and completes the questionnaire, and has signed the informed consent form and committed to follow-up

Exclusion criteria

Exclusion criteria: 1. Menstruating women, pregnant women, or breastfeeding women 2. Presence of systemic diseases, such as coagulation disorders, cardiovascular and cerebrovascular diseases, or endocrine diseases 3. Allergy to chamomile, lidocaine, or intraoperative use of artemisinin hydrochloride used in this study 4. History of taking any analgesics within the past week, or long-term medication use 5. Presence of untreated dental pain conditions, such as pulpitis, periodontitis with apical inflammation, or trigeminal neuralgia, requiring long-term analgesia 6. History of invasive dental treatment within the past week 7. Concurrent acute oral infection or tumor 8. Alcohol consumption within one week before surgery 9. Active or past history of digestive ulcers, gastrointestinal bleeding, or perforation; 10. Currently using ibuprofen, selective cyclooxygenase-2 (COX-2) inhibitors, or other non-steroidal anti-inflammatory drugs; 11. History of previous surgery.

Design outcomes

Primary

MeasureTime frame
NRS Pain Score measured using NRS Pain Assessment Questionnaire at 2 hours, 6 hours, 12 hours after surgery, 1 day, 2 days, 3 days, 5 days, 7 days after surgery

Secondary

MeasureTime frame
Frequency and dosage of painkillers measured using Questionnaire at Within 7 days after surgery;The degree of facial swelling measured using The tape measure method described by Gabka and Matsumara at The third day after surgery

Countries

China

Contacts

Public ContactMeng-Di Nie
xndm688@163.com+86 18286842858

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jul 3, 2026