Screening and personality-aspects in post-traumatic stress disorder (PTSD) - substance use disorder patients

A study on the psychometric qualities of post-traumatic stress disorder (PTSD) screeners and the role of personality (measured by the NEO Five-Factor Inventory [NEO-FFI]) in patients with the comorbid diagnosis of PTSD and substance use disorder (SUD)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN42030125

Enrollment

200

Registered

2009-02-27

Start date

2008-11-15

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-traumatic stress disorder, substance use disorder Mental and Behavioural Disorders Reaction to severe stress, and adjustment disorders

Interventions

This observational cross-sectional study examines whether patients in four addiction centres meet criteria for PTSD as well as criteria for SUD. Participants will be asked to complete the following as

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients who are at least 18 years old, both males and females 2. Patients of addiction treatment centres who are inpatient for at least 4 weeks 3. Patients who meet the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (with text revision) (DSM-IV-TR) criteria for Substance Use Disorder

Exclusion criteria

Exclusion criteria: 1. Inadequate level of the Dutch language 2. Severe cognitive impairment or damage 3. Severe (self) destructive behaviour If a practitioner declares the patient is incapable of participation, the patient will be excluded.

Design outcomes

Primary

Measure	Time frame
1. Sensitivity and specificity of ZIL and MINI plus (PTSD section), with KIP as gold standard 2. Difference between the NEO FFI profiles of the group PTSD-SUD and the group SUD-PTSD	—

Secondary

Measure	Time frame
1. History of several kinds of trauma, severity and time-course are carefully traced by VBE. Comparison will be made between groups that differ in the order of onset of the comorbid disorders, with regard to various outcomes of VBE (nature of trauma, duration, severity, age at onset). 2. Psychometric qualities of DASS in detecting PTSD in relation to other instruments (KIP, ZIL, M.I.N.I.-plus) 3. Alexithymia, assessed by TAS-20 and BVAQ	—

Measure

Time frame

1. History of several kinds of trauma, severity and time-course are carefully traced by VBE. Comparison will be made between groups that differ in the order of onset of the comorbid disorders, with regard to various outcomes of VBE (nature of trauma, duration, severity, age at onset). 2. Psychometric qualities of DASS in detecting PTSD in relation to other instruments (KIP, ZIL, M.I.N.I.-plus) 3. Alexithymia, assessed by TAS-20 and BVAQ

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Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026