Understanding the relationship between uterine artery Doppler measurements (blood flow to the placenta) and aspirin response

Sequential analysis of uterine artery Doppler waveforms in high-risk population for placenta-mediated disease undergoing prophylactic aspirin therapy controlled by levels of serum thromboxane

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN41944844

Enrollment

294

Registered

2019-04-23

Start date

2017-06-01

Completion date

Unknown

Last updated

2024-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preeclampsia Pregnancy and Childbirth Pre-eclampsia

Interventions

1. Change in the blood flow calculated from routine uterine artery Doppler examination at 12 and 20 weeks gestation 2. Urine and blood test at 20 weeks gestation looking at the levels of Thromboxane

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Women at risk of preeclampsia according to NICE criteria

Exclusion criteria

Exclusion criteria: Unable to give informed consent

Design outcomes

Primary

Measure	Time frame
Level of serum Thromboxane B2 measured in blood at 20 weeks gestation	—

Secondary

Measure	Time frame
Pregnancy outcome (i.e. preeclampsia) at delivery of the baby	—

Countries

England, United Kingdom

Contacts

Public ContactRaya Vinogradov

raya.vinogradov@ncl.ac.uk+44 (0)191 2820540

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026