Cardiac resynchronisation therapy, heart failure Circulatory System
Conditions
Interventions
People with heart failure who are referred for a special pacemaker treatment called cardiac resynchronisation therapy (CRT) will be invited to take part. Everyone will have their usual heart assessmen
Sponsors
King's College London
Eligibility
Sex/Gender
All
Age
18 Years to 120 Years
Inclusion criteria
Inclusion criteria: Current key inclusion criteria as of 22/06/2026: 1. Age =18 years 2. Good understanding of English 3. Receiving optimal medical therapy for heart failure 4. Fulfilling current guideline criteria for cardiac resynchronisation therapy (CRT), including CRT-P, CRT-D, and conduction system pacing (NYHA Class II–IV, LVEF =35%, and QRS duration >130 ms) _____ Previous key inclusion criteria: 1. Age over 18 years 2. Strong understanding of English 3. On optimal medical therapy for heart failure 4. Fulfilling standard consensuses guidelines (NYHA class II-IV, EF =35% and QRS duration>130ms) for CRT ( including conduction pacing system)
Exclusion criteria
Exclusion criteria: Current key exclusion criteria as of 22/06/2026: 1. Co-morbidity expected to reduce life expectancy to less than 6 months 2. Major cardiovascular event within the previous 6 weeks 3. More than mild aortic stenosis 4. Continuous or intermittent infusion therapy for heart failure 5. Suboptimal ultrasound acoustic window 6. Inability to provide informed consent 7. Current participation in another interventional study that, in the opinion of the Chief Investigator, may interfere with the objectives or assessments of this study _____ Previous key exclusion criteria: 1. Co-morbidity expected to reduce life expectancy to less than 6 months 2. Major cardiovascular event in the previous 6 weeks 3. More than mild aortic stenosis 4. Continuous or intermittent infusion therapy for heart failure 5. Suboptimal ultrasound acoustic window 6. Inability to give informed consent 7. Current participant in other interventional studies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Volumetric response measured as a reduction in left ventricular end-systolic volume >15% using echocardiography at 6 months after CRT implantation. Clinical improvement measured using the Clinical Composite Score (CCS) at 6 months after CRT implantation | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospitalisation for heart failure or death (clinical events reviewed from patient medical records and telephone call) at 36 months after CRT implantation | — |
Countries
England, United Kingdom
Contacts
Public ContactHaotian Gu
Outcome results
None listed