Preimplantation genetic screening (PGS) by array-comparative genomic hybridization (CGH) on day 5 embryos with day 6 fresh transfer in repeated implantation failure (RIF) patients

Preimplantation genetic screening (PGS) by array-comparative genomic hybridization (CGH) on day 5 embryos with day 6 fresh transfer in repeated implantation failure (RIF) patients: a randomised double-blinded study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN41698043

Enrollment

200

Registered

2011-12-09

Start date

2011-12-01

Completion date

Unknown

Last updated

2017-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility Urological and Genital Diseases Female infertility, unspecified

Interventions

Control group: ICSI procedure, day 5 Laser Assisted drilling without Preimplantaion Genetic Screening, day 6 embryo transfer Study group: ICSI and Preimplantation Genetic Screening with array-CGH, em

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Female patients aged 36 years old or younger undergoing an Intra-cytoplasmic sperm injection (ICSI) attempt at GENERA Clinic in Rome 2. History of more than two failed In vitro fertilisation (IVF)/ICSI cycles; without clinical pregnancy with transfer of at least one good quality embryos per transfer 3 .=6 metaphase II (MII) oocytes retrieved 4. Signed consent form

Exclusion criteria

Exclusion criteria: 1. Azoospermic male partner 2. Severe male factor infertility defined as ejaculate sperm of 35, uncontrolled hypertension, anti-phospholipid antibody, thrombophilia, insulin dependent diabetes)

Design outcomes

Primary

Measure	Time frame
Live birth rate [Time Frame: 1 year after embryo transfer]; pregnancies that arrive to term divided by procedures with an egg retrieval	—

Secondary

Measure	Time frame
1. Ongoing pregnancy rate per embryo transfer [Time Frame: 20 weeks after embryo transfer]. Ongoing pregnancy defined as the presence of a fetal sac. Pregnancy rate per transfer defined as pregnancies divided by patients with a replacement of embryos. 2. Pregnancy rate per retrieval [Time Frame: 20 weeks after embryo transfer]. pregnancy defined as the presence of a fetal sac. Pregnancy rate per retrieval defined as pregnancies divided by patients with an egg retrieval. 3. Ongoing pregnancy rate per started cycle [ Time Frame: 20 weeks after embryo transfer ] 4. Ongoing implantation rate [Time Frame: 12 weeks after embryo transfer ] 5. Number of embryos implanted divided by number of embryos replaced. An embryo implanted is measured as a fetal sac by ultrasound observation. 6. Embryo transfer rate per started cycle	—

Measure

Time frame

1. Ongoing pregnancy rate per embryo transfer [Time Frame: 20 weeks after embryo transfer]. Ongoing pregnancy defined as the presence of a fetal sac. Pregnancy rate per transfer defined as pregnancies divided by patients with a replacement of embryos. 2. Pregnancy rate per retrieval [Time Frame: 20 weeks after embryo transfer]. pregnancy defined as the presence of a fetal sac. Pregnancy rate per retrieval defined as pregnancies divided by patients with an egg retrieval. 3. Ongoing pregnancy rate per started cycle [ Time Frame: 20 weeks after embryo transfer ] 4. Ongoing implantation rate [Time Frame: 12 weeks after embryo transfer ] 5. Number of embryos implanted divided by number of embryos replaced. An embryo implanted is measured as a fetal sac by ultrasound observation. 6. Embryo transfer rate per started cycle

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Countries

Italy

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026