Multiple sclerosis Nervous System Diseases Multiple sclerosis
Conditions
Interventions
The researchers will undertake array-based genome-wide genotyping in DNA extracted from patients' venous blood or saliva
Sponsors
Cambridge University Hospitals NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. A locally confirmed diagnosis of multiple sclerosis 2. At least one measure of Extended Disability Severity Score (EDSS) 3. Able to give valid informed consent
Exclusion criteria
Exclusion criteria: 1. Patients with Radiologically or Clinically Isolated Syndrome (RIS or CIS) 2. Comorbidities causing significant disability likely to have confounded the reliability of the EDSS 3. Inclusion in the discovery cohort of the recently completed first progression GWAS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disability measured using the Extended Disability Status Scale (EDSS) and age-corrected to generate the Age-Related Multiple Sclerosis Severity (ARMSS) Score. All available measures of the ARMSS will be considered in the analysis as observed at any timepoint in the disease course. | — |
Secondary
| Measure | Time frame |
|---|---|
| TIme to event measures including time to EDSS 6.0 and time to confirmed disability worsening. These variables will be assessed in the sub-group of patients with EDSS measured at multiple timepoints. | — |
Countries
England, United Kingdom
Contacts
Public ContactStephen Sawcer
Outcome results
None listed