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Examination of caries activity of children by investigating the dental plaque and saliva

Investigation Of Urease And Arginine Deiminase Activity In Dental Plaque And Saliva of Children

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN41631598
Enrollment
34
Registered
2019-07-12
Start date
2017-01-02
Completion date
Unknown
Last updated
2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental caries Digestive System Dental caries

Interventions

Oral and dental health evaluation was performed by an experienced pediatric dentist using a dental mirror, dental explorer and a World Health Organization periodontal probe. In the clinical examinatio
dmf(t), plaque index (Silness Loe plaque index) and gingival index (Loe and Silness) values were determined and unstimulated salivary flow rate and buffering capacity (BC) were calculated. The saliva

Sponsors

Scientific Research Projects of Istanbul University.
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged between 4 and 6 years old. 2. Unerupted first permanent molars. 3. No history of any systemic disease. 4. No history of antibiotic use within the recent three months. 5. No use of oral care product containing arginine. 6. No history of periodontal disease. 7. Not any applied fixed or removable retainers.

Exclusion criteria

Exclusion criteria: N/A

Design outcomes

Primary

MeasureTime frame
Urease and ADS activities are measured using a spectrophotometric assay at baseline, at the end of and 3 months after dental treatment using a spectrophotometric assay.

Secondary

MeasureTime frame
1. Dental caries prevalence is evaluated using (dmf(t) at the end of and 3 months after treatment. 2..Oral hygiene is evaluated using the Silness Loe plaque index at the end of and 3 months after treatment. 3. Periodontal health is evaluated using the Loe and Silness gingival index at the end of and 3 months after treatment. 4. Saliva activity is evaluated using unstimulated salivary flow rate at the end of and 3 months after treatment. 5. Saliva activity is evaluated using buffering capacity (BC)) at the end of and 3 months after treatment.

Countries

Turkey

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026