The effect of vitamin D supplementation on muscle strength and function in UK South Asian women

A randomized placebo-controlled trial to investigate the effect of vitamin D supplementation on muscle strength and function in UK South Asian post-menopausal women

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN41610200

Enrollment

100

Registered

2019-03-04

Start date

2019-03-04

Completion date

Unknown

Last updated

2020-07-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitamin D deficiency Nutritional, Metabolic, Endocrine Vitamin D deficiency

Interventions

This is a double blinded randomised (added 13/07/2020) placebo controlled trial. Both treatment arms will be treated identically. Postmenopausal South Asian women (aged 60-75) will b

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. South Asian women (Indians and Pakistanis) 2. Aged 60-75 years 3. Able to walk without assistance

Exclusion criteria

Exclusion criteria: Current exclusion criteria as of 13/07/2020: 1. vitamin D supplement user 2. Multi-vitamin user, cod liver oil user 3. Found to have vitamin D status equal or above than 50nmol/L at baseline/screening stage 4. Impaired cognition Previous exclusion criteria: 1. vitamin D supplement user 2. Multi-vitamin user, cod liver oil user 3. Found to have vitamin D status equal or above than 50nmol/L at baseline screening 4. Impaired cognition

Design outcomes

Primary

Measure	Time frame
Single chair stand as an indicator of lower limb muscle strength assessed using a stopwatch at baseline and following 12 weeks of vitamin D supplementation.	—

Secondary

Measure	Time frame
1. Circulating vitamin D level (nmol/L) will be measured at entry to determine vitamin D status and after 12 weeks supplementation to assess the ability of the supplement to replete vitamin D status. Measured using mass spectrometry. 2. Short physical performance battery (SPPB) [repeated chair stand test (s), balance test (s) and timed up and go test (s)] will be performed at baseline and at 12 weeks of vitamin D supplementation as parameter of muscle strength and function. Measured using a stopwatch. 3. Hand-grip strength (kg) of both hands will be performed at baseline and at 12 weeks as an indicator of upper limb muscle strength. Measured using Jamar hand dynamometry. 4. Walking speed test (s) will be performed at baseline and at 12 weeks as parameter of muscle function. Measured using a stopwatch. 5. Body fat and muscle mass will be measured at baseline and at 12 weeks as parameter of body composition. Measured using Bioelectrical Impedance. 6. General interview (demographic, anthropometric and health history etc) will be conducted at start and exist. 7. Pre and post course self-reported physical activity interview by using international physical activity questionnaire (IPAQ) - short form. 8. Diet and nutrition knowledge interview will be conducted once during the study.	—

Measure

Time frame

1. Circulating vitamin D level (nmol/L) will be measured at entry to determine vitamin D status and after 12 weeks supplementation to assess the ability of the supplement to replete vitamin D status. Measured using mass spectrometry. 2. Short physical performance battery (SPPB) [repeated chair stand test (s), balance test (s) and timed up and go test (s)] will be performed at baseline and at 12 weeks of vitamin D supplementation as parameter of muscle strength and function. Measured using a stopwatch. 3. Hand-grip strength (kg) of both hands will be performed at baseline and at 12 weeks as an indicator of upper limb muscle strength. Measured using Jamar hand dynamometry. 4. Walking speed test (s) will be performed at baseline and at 12 weeks as parameter of muscle function. Measured using a stopwatch. 5. Body fat and muscle mass will be measured at baseline and at 12 weeks as parameter of body composition. Measured using Bioelectrical Impedance. 6. General interview (demographic, anthropometric and health history etc) will be conducted at start and exist. 7. Pre and post course self-reported physical activity interview by using international physical activity questionnaire (IPAQ) - short form. 8. Diet and nutrition knowledge interview will be conducted once during the study.

—

Countries

United Kingdom

Contacts

Public ContactSabeen Zahra

szahra1@sheffield.ac.uk07925034704

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026