Multiple sclerosis Nervous System Diseases Multiple sclerosis
Conditions
Interventions
Exercise Group:
A 12-week intervention period is planned for the exercise group, with a more frequent contact phase during the first 6-week block (two supervised exercise sessions at the centre and o
Sponsors
Sheffield Teaching Hospitals NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Clinical diagnosis of MS with an Expanded Disability Status Scale (EDSS) score of between 1.0 - 6.5, and able to walk 10 m distance 2. Aged 18 - 65 years, either sex 3. Participants must have been clinically stable for at least 4 weeks prior to entering the study 4. Participants on disease modifying therapy (interferon and glatiramer acetate) must have been stable on this treatment for at least 3 months prior to entering the study 5. Physically able to participate in some form of exercise three times per week 6. Able to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. Failure to meet any of the above inclusion criteria 2. Experiencing illness that impairs their ability to be physically active three times per week 3. Not willing to be randomised to either the exercise intervention or usual care control group 4. Living more than 20 miles from the trial centre 5. Already engaged in purposeful structured exercise or brisk walking exercise for equal to or greater than three times per week for equal to or greater than 30 minutes per session and have been so on a consistent basis during the previous six months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Physical activity levels 2. Six-minute walking test All outcome measures will be taken at baseline, 12-weeks and at 6-months follow-up. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Neurological impairment and clinical functional mobility 2. Quality of life 3. Fatigue 4. Focus groups and interviews 5. Immunological analysis All outcome measures will be taken at baseline, 12-weeks and at 6-months follow-up. | — |
Countries
United Kingdom
Outcome results
None listed