The use of non-invasive ventilation immediately after extubation to improve the weaning outcome in acute respiratory failure

Efficacy of non-invasive positive pressure ventilation to prevent re-intubation and to improve hospital mortality after weaning in acute respiratory failure: a randomised, prospective study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN41524441

Enrollment

Registered

2008-08-21

Start date

1998-01-15

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory failure Respiratory Respiratory failure, not elsewhere classified

Interventions

After the patients achieved elective extubation criteria they were randomised to receive non-invasive positive pressure ventilation immediately after extubation or receive oxygen mask alone. The tota

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients aged 18 years or older, either sex 2. Need more than three days of mechanical ventilation administered by orotracheal intubation because of acute respiratory failure 3. Weaning from invasive mechanical ventilation using intensive care unit (ICU) weaning protocol 4. Absence of contraindications for the use of non-invasive ventilation

Exclusion criteria

Exclusion criteria: 1. Less than 18 years of age 2. Pregnancy 3. Patients refusal to participate in the study

Design outcomes

Primary

Measure	Time frame
Decrement in the need of re-intubation, measured within 48 hours of extubation	—

Secondary

Measure	Time frame
1. Decrement of ICU length of stay 2. Decrement of hospital mortality	—

Countries

Brazil

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026