Diagnostic efficacy and effectiveness of primary whole-body computed tomography (Pan-CT) in severe and multiple trauma

Primary whole-body computed tomography (Pan-CT) for Trauma Resuscitation Evaluation: a prospective diagnostic effectiveness trial with a retrospective diagnostic accuracy study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN41462125

Enrollment

700

Registered

2009-09-18

Start date

2009-09-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blunt and penetrating multiple trauma Injury, Occupational Diseases, Poisoning

Interventions

PATRES-1: Hospital charts and RIS/PACS data of the patients will be studied retrospectively to determine diagnostic accuracy of Pan-CT. PATRES-2: Prospective observational study of patients undergoi

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: PATRES-1: Hospital charts and Radiology Information System/Picture Archiving and Communication System (RIS/PACS) data from consecutive male and female patients (no age limits) who i) had been admitted to the emergency department of a metropolitan trauma centre between 01/2008 and 06/2009 and ii) were referred to Pan-CT because of suspected multiple trauma by the physician on charge PATRES-2: Trauma leaders caring for consecutive male and female patients (no age limits) who are admitted to the emergency department of a metropolitan trauma centre and are referred to Pan-CT because of suspected multiple trauma

Exclusion criteria

Exclusion criteria: Does not meet inclusion criteria

Design outcomes

Primary

Measure	Time frame
PATRES-1: Accuracy of Pan-CT (i.e. sensitivity, specificity, area under the ROC curve) for diagnosing i) multiple trauma, ii) individual injuries. A synopsis of all diagnoses obtained during the hospital stay (e.g. CT-scans, clinical, intra-operative, and autopsy findings) will serve as the reference standard. All images will be re-read by experienced trauma radiologists, and hospital charts will independently be evaluated by trauma surgeons. PATRES-2: 1. Shift in the pre-test probability of the prevalence and severity of injuries as judged by trauma surgeons prior to and after Pan-CT 2. Related changes in clinical decision making (e.g., emergency surgery, transfer to intensive care unit [ICU])	—

Measure

Time frame

PATRES-1: Accuracy of Pan-CT (i.e. sensitivity, specificity, area under the ROC curve) for diagnosing i) multiple trauma, ii) individual injuries. A synopsis of all diagnoses obtained during the hospital stay (e.g. CT-scans, clinical, intra-operative, and autopsy findings) will serve as the reference standard. All images will be re-read by experienced trauma radiologists, and hospital charts will independently be evaluated by trauma surgeons. PATRES-2: 1. Shift in the pre-test probability of the prevalence and severity of injuries as judged by trauma surgeons prior to and after Pan-CT 2. Related changes in clinical decision making (e.g., emergency surgery, transfer to intensive care unit [ICU])

—

Secondary

Measure	Time frame
PATRES-1: 1. Rate of unnecessary CT-scans 2. Discrepancy between first and second readings PATRES-2: Perceived value and effectiveness of CT-scans by trauma leaders (immediately after availability of CT-scans [i.e. at the trauma bay])	—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 27, 2026