Cardiovascular disease Circulatory System Complications and ill-defined descriptions of heart disease
Conditions
Interventions
Individuals will have an initial two-week run-in period where dietary salt advice is given to achieve a salt reduction of 6 g. They are then randomised by computer-generated random allocation to eithe
Sponsors
St George's University of London (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 30 to 80 years, either sex 2. Untreated blood pressure of greater than 120/70 mmHg with impaired glucose tolerance on oral glucose tolerance test or diet controlled type two diabetes
Exclusion criteria
Exclusion criteria: 1. Uncontrolled hypertension (blood pressure greater than 160/100 mmHg) 2. Type two diabetes on oral hypoglycaemic agents or insulin 3. Secondary hypertension 4. Uncontrolled heart failure or active ischaemic heart disease 5. Active malignancy or liver disease 6. Females who are pregnant, breast feeding or taking the oral contraceptive pill 7. Individuals started on lipid lowering therapy within the last three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Casual systolic and diastolic blood pressure. Primary outcomes are measured at baseline and weeks 2, 5, 8, 11 and 14. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Urinary albumin excretion 2. Ambulatory blood pressure monitoring (ABPM) 3. Endothelial function 4. Arterial stiffness Secondary outcomes are measured at baseline and weeks 8 and 14. | — |
Countries
United Kingdom
Outcome results
None listed