A randomised trial of on pump beating heart surgery and blood cardioplegia in patients with impaired left ventricular function using cardiac magnetic resonance imaging and biochemical markers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN41388968

Enrollment

Registered

2006-02-03

Start date

2005-11-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischaemic heart disease Circulatory System Chronic ischaemic heart disease

Interventions

The trial involves comparing standard on pump warm blood cardioplegia coronary artery bypass grafting to a modified surgical technique where the patient undergoes beating heart surgery but is maintain

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Ejection fraction less than 30% 2. Creatinine less than 170 µmol/l

Exclusion criteria

Exclusion criteria: 1. Contra-indications to MRI scanning 2. Claustrophobia

Design outcomes

Primary

Measure	Time frame
1. End systolic volume index 2. End diastolic volume index	—

Secondary

Measure	Time frame
1. Hospital stay 2. Mortality 3. Creatine kinase myocardial bands (CKMB) 4. Troponin 5. Ventilation 6. Dialysis 7. Intra-aortic balloon pump (IABP) duration 8. Peak creatinine	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 30, 2026