Surgery: Carotid endarterectomy Surgery Carotid endarterectomy
Conditions
Interventions
All patients undergoing carotid endarterectomy will receive a standardised general anaesthetic.
The patients in the study will be randomised to the treatment group who will receive a superficial cerv
Sponsors
Record Provided by the NHSTCT Register - 2005 Update - Department of Health (UK)
Eligibility
Inclusion criteria
Inclusion criteria: The patients will be selected from all patients presenting for carotid endarterectomy. The vast majority of these patients are now seen in the vascular preadmission clinic by a consultant anaesthetist. This clinic will provide the opportunity to discuss the project with the patients. They would then be able to consider at home prior to admission whether or not to participate. Consent where relevant would then be taken at the time of admission. Approximately 100 patients undergo this operation annually in the trust. We need to recruit at least 54 patients and we would hope to achieve this over 1 year.
Exclusion criteria
Exclusion criteria: Patients will be excluded if they have a contraindication to a block, such as coagulopathy, thrombocytopenia, treatment with clopidogrel or multiple anti-platelet agents within one week of surgery. Other exclusions will be patient refusal and known local anaesthetic allergy. In order to account for the potential influence of beta-blockade, only patients on perioperative beta blockade will be studied. Patients will therefore be excluded if they have a contraindication to beta-blockade. 1. Patients will be excluded if they do not wish to take part in this trial 2. Contra-indication to beta blockage therapy 3. Increase risk of bleeding (ie patients with low platelet counts , coagulopathy associated with liver dysfunction, treatment with multiple antiplatelet agents or treatment with clopidogrel in the 7 days prior to surgery) 4. Patients with known allergy to local anaesthetics
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes will include the need for vasopressor or antihypertensive medication, cumulative opiate requirements, and mean pain scores in recovery and HDU. Any major cardiovascular or cerebrovascular morbidity or mortality in the first 24 hours, and any side effects potentially related to the block will be recorded. | — |
Primary
| Measure | Time frame |
|---|---|
| Mean systolic blood pressure over the first 24 hours following surgery. | — |
Countries
United Kingdom
Outcome results
None listed