Feasibility of amide proton transfer imaging in children and adolescents with brain tumours

Feasibility of amide proton transfer chemical exchange saturation transfer in paediatric, teenage and young adult gliomas

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN41243307

Enrollment

Registered

2022-03-06

Start date

2016-04-01

Completion date

Unknown

Last updated

2022-05-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glioma Cancer

Interventions

The participant is recruited from clinic by their normal doctor and is asked to undergo a PET-MRI study. The patient is given an information sheet and If the patient agrees, they are booked for a scan

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients aged 12-20 years undergoing treatment for glioma

Exclusion criteria

Exclusion criteria: 1. Pregnant 2. Other cancer

Design outcomes

Primary

Measure	Time frame
Glioma tumour cell proliferation measured using amide proton transfer chemical exchange saturation transfer (APT-CEST) and 18F-fluoromethylcholine (18F-choline) positron emission tomography (PET) standardised uptake value (SUV) at baseline	—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026