Impact of maternal and infant geohelminth infections on atopy and vaccine immunity in infants living in rural tropical region of Ecuador [Impacto de las infecciones con geohelmintos en madres embarazadas e infantes sobre atopia e inmunidad a vacunas en infantes que viven en zonas rurales tropicales del Ecuador]

Conditions

Vaccine immunity, allergic sensitisation, eczema, asthma Not Applicable Immunisation

Philip J. Cooper, Irina Chis Ster, Martha Chico, Maritza Vaca, Yisela Oviedo et al. (9 authors)

Allergy2021-03-2116 citations

10.1111/all.14821

Effect of Early-Life Geohelminth Infections on the Development of Wheezing at 5 Years of Age

Philip J. Cooper, Martha Chico, Maritza Vaca, Carlos Sandoval, Sofia Loor et al. (9 authors)

American Journal of Respiratory and Critical Care Medicine2017-09-2835 citations

10.1164/rccm.201706-1222oc

Impact of early life exposures to geohelminth infections on the development of vaccine immunity, allergic sensitization, and allergic inflammatory diseases in children living in tropical Ecuador: the ECUAVIDA birth cohort study.

Cooper PJ, Chico ME, Guadalupe I, Sandoval CA, Mitre E, Platts-Mills TA, Barreto ML, Rodrigues LC, Strachan DP, Griffin GE.

2011-06-2936 citations

10.1186/1471-2334-11-184

Interventions

The primary exposures are maternal geohelminth infections and infant infections during the first 2 years of life. Stool samples are collected during pregnancy or at the time of birth to determine mate

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Neonate born within the previous 14 days 2. Gestational age of at least 34 weeks 3. At least one stool sample collected during third trimester of pregnancy 4. The mother lives within the geographic limits of the District of Quininde, Esmeraldas Province 5. The mother plans to live within the District of Quininde, Esmeraldas Province for at least 3 years 6. The mother's household is accessible

Exclusion criteria

Exclusion criteria: 1. Neonate of greater than 14 days age 2. Gestational age less than 34 weeks 3. No stool sample collected during third trimester of pregnancy 4. The mother does not live within the geographic limits of the District of Quininde, Esmeraldas Province 5. The mother does not plan to live within the District of Quininde, Esmeraldas Province for at least 3 years 6. The mother's household is not easily accessible

Design outcomes

Primary

Measure	Time frame
1. Vaccine immunity: protective levels of antibodies to rotavirus, Hemophilus influenzae type B, hepatitis B virus, OPV serotype 3, and tetanus toxoid 2. Allergic sensitization: allergen skin test reactivity to at least one aeroallergen tested 3. Eczema: at least one presentation with eczema by 3 years of age 4. Asthma: Asthma diagnosed at 5 years of age	—

Secondary

Measure	Time frame
Studies of intermediate immunological mechanisms that mediate exposure-outcome effects including: 1. Immune homeostasis: measured by spontaneous IL-10 in whole blood 2. Immune regulation/suppression - IL-10 to tetanus toxoid (TT), tuberculin (PPD), Ascaris lumbricoides or Dermatophagoides pteronyssinus 3. Th2 polarization - ratio of IL-5 to IFN-g TT, PPD or Staphylococcus enterotoxin B 4. Pro-inflammatory responses - IL-8 to endotoxin These responses will be measured at 2, 3, or 5 years depending on the relevant exposure-outcome association.	—

Measure

Time frame

Studies of intermediate immunological mechanisms that mediate exposure-outcome effects including: 1. Immune homeostasis: measured by spontaneous IL-10 in whole blood 2. Immune regulation/suppression - IL-10 to tetanus toxoid (TT), tuberculin (PPD), Ascaris lumbricoides or Dermatophagoides pteronyssinus 3. Th2 polarization - ratio of IL-5 to IFN-g TT, PPD or Staphylococcus enterotoxin B 4. Pro-inflammatory responses - IL-8 to endotoxin These responses will be measured at 2, 3, or 5 years depending on the relevant exposure-outcome association.

—

Countries

Ecuador

Outcome results

None listed