Other disorders of glucose regulation and pancreatic internal secretion Nutritional, Metabolic, Endocrine
Conditions
Interventions
During the study visits, participants will be given either bread or a glucose solution. The 10 test breads will vary in fiber content, and each type of bread will be consumed once on separate occasion
Sponsors
Imperial College London
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18-65 years (inclusive) 2. Body mass index (BMI) of 18-30 kg/m2 3. Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements.
Exclusion criteria
Exclusion criteria: 1. Screening blood results outside of normal reference values 2. Weight change of > = 5kg in the preceding 2 months 3. Current smokers 4. History of substance abuse and/or excess alcohol intake 5. Pregnancy 6. Diabetes 7. Cardiovascular disease 8. Cancer 9. Gastrointestinal disease e.g. inflammatory bowel disease or irritable bowel syndrome 11. Kidney disease 12. Liver disease 13. Pancreatitis 14. Having polycystic ovary syndrome (PCOS) 15. Started new medication within the last 3 months likely to interfere with energy metabolism, appetite regulation and hormonal balance, including anti-inflammatory drugs or steroids, antibiotics, androgens, phenytoin, erythromycin or thyroid hormones. 16. Subjects who are currently participating in other clinical trials 17. Any blood donation within the 12 week period prior to entering this study 18. Subjects who are unable to give informed consent by themselves
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood glucose levels measured via the glycaemic response measured in blood samples collected by cannulation at 15, 30, 45, 60, 90, and 120 minutes post-consumption. | — |
Secondary
| Measure | Time frame |
|---|---|
| Current secondary outcome as of 20/08/2026: Blood insulin, GIP and C-peptide levels measured in blood samples collected by cannulation at 15, 30, 45, 60, 90, and 120 minutes post-consumption. Previous secondary outcome: Blood insulin and C-peptide levels measured in blood samples collected by cannulation at 15, 30, 45, 60, 90, and 120 minutes post-consumption. | — |
Countries
England, United Kingdom
Contacts
Public ContactGary Frost
Outcome results
None listed