Collecting data on patients with a breast cancer who undergo or do not undergo magnetic resonance imaging (MRI) before surgery

Preoperative breast MRI in clinical practice: Multicenter International Prospective meta-Analysis (MIPA) of individual woman data

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN41143178

Enrollment

7000

Registered

2013-08-30

Start date

2013-07-01

Completion date

Unknown

Last updated

2019-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast cancer Cancer Malignant neoplasm of breast

Interventions

Data on consecutive series of women with a newly diagnosed first breast cancer, not candidate to neoadjuvant chemotherapy, who undergo (MRI-group) or not (no-MRI group) undergo preoperative MRI, will

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Women from 18 to 80 years of age with a newly diagnosed needle-biopsy proven first breast cancer

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Previous history of non-breast cancer at any site 3. Previous history of breast cancer (invasive or DCIS) 4. Women candidates to neoadjuvant chemotherapy 5. Women with evidence of distant metastases at the time of breast MRI 6. Women with absolute contraindications to MRI or to gadolinium-based contrast materials according to international guidelines or local regulations (including eGFR <30 ml/min*1.73 m2) 7. Women who received any contrast material prior to breast MRI examination or are scheduled to receive any contrast material within 24 hour afterwards 8. Mental disability precluding informed consent to participate

Design outcomes

Primary

Measure	Time frame
1. Proportion of patients receiving re-excision due to positive or close surgical margins 2. Overall rate of unilateral (or bilateral) mastectomy	—

Secondary

Measure	Time frame
1. Rate of change of surgical planning from that planned on basis of conventional imaging to that recommended on the basis of MRI findings in the MRI-group 2. Ipsilateral recurrence during 5-year follow-up 3. Contralateral breast cancer during 5-year follow-up 4. Diagnosis of distant metastases (confirmed by at least two imaging techniques) during 5-year follow-up	—

Countries

Australia, Austria, Belgium, Brazil, Denmark, France, Germany, Hungary, Ireland, Italy, Netherlands, Russian Federation, Spain, Turkey, United Kingdom, United States of America

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026