Surveillance towards preventing RSV respiratory infection in paediatrics

Surveillance towards preventing paediatric: incidence RSV attributable (lower respiratory tract infection) in primary and secondary/tertiary healthcare settings in Merseyside and Bristol, UK

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN41075797

Enrollment

1800

Registered

2022-08-08

Start date

2021-12-12

Completion date

Unknown

Last updated

2023-06-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory syncytial virus (RSV) Infections and Infestations

Interventions

Current interventions as of 23/01/2023: The main study is an observational surveillance study of the incidence and burden of RSV attributable to lower respiratory tract infection (LRTI

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Infants and children aged <3 years who present to primary or secondary/tertiary healthcare with symptoms of LRTI

Exclusion criteria

Exclusion criteria: If they have already been to recruited to the study prior to 30 days

Design outcomes

Primary

Measure	Time frame
Point prevalence (95% confidence intervals) of RSV-positive nasal swabs measured by PCR at baseline	—

Secondary

Measure	Time frame
1. Frequency and proportion of positive cases presenting in each category of health care using data searches to determine any lab-confirmed RSV cases reported at the individual sites during the period of recruitment to the study 2. Detection of other respiratory pathogens including influenza A/B, SARS-CoV2, and S. pneumoniae by PCR test on a nasal swab taken at baseline 3. Demographic data, medical history, baseline observations, severity of illness score, and health care utilisation in relation to URTI/LRTI symptoms prior to recruitment, measured using data collected at baseline 4. Data collected from medical records and questionnaires on days 14 and 28: 4.1. Proportion of participants with ongoing symptoms 4.2. Hospital duration (days) (median interquartile range [IQR]) 4.3. Level of care (emergency department [ED]/ward/high dependency unit (HDU)/paediatric intensive care unit [PICU]) 4.4. Duration and type of respiratory support (days) (median IQR) 4.5. Frequency of radiological assessments: x-rays etc 4.6. Frequency of GP or other primary care visits 4.7. Quality of life measured using PEDS QL and EQ-5D-3L 5. Health care data from existing metrics on the impact and opportunity costs of RSV over the peak winter RSV season from October to March at Alder Hey Children’s Hospital: 5.1. Number of cancelled elective cases 5.2. Seasonal reduction in bed availability (number of bed days lost due to increase in respiratory infection cases) 5.3. Number of episodes children with respiratory symptoms are transferred to or retrieved from other PICUs 6. Existing health care data (anonymised) using data codes (HES/PICANET/ICD and SNOMED codes) for respiratory infection in children under age 3 years at recruiting sites during the period of rec	—

Measure

Time frame

1. Frequency and proportion of positive cases presenting in each category of health care using data searches to determine any lab-confirmed RSV cases reported at the individual sites during the period of recruitment to the study 2. Detection of other respiratory pathogens including influenza A/B, SARS-CoV2, and S. pneumoniae by PCR test on a nasal swab taken at baseline 3. Demographic data, medical history, baseline observations, severity of illness score, and health care utilisation in relation to URTI/LRTI symptoms prior to recruitment, measured using data collected at baseline 4. Data collected from medical records and questionnaires on days 14 and 28: 4.1. Proportion of participants with ongoing symptoms 4.2. Hospital duration (days) (median interquartile range [IQR]) 4.3. Level of care (emergency department [ED]/ward/high dependency unit (HDU)/paediatric intensive care unit [PICU]) 4.4. Duration and type of respiratory support (days) (median IQR) 4.5. Frequency of radiological assessments: x-rays etc 4.6. Frequency of GP or other primary care visits 4.7. Quality of life measured using PEDS QL and EQ-5D-3L 5. Health care data from existing metrics on the impact and opportunity costs of RSV over the peak winter RSV season from October to March at Alder Hey Children’s Hospital: 5.1. Number of cancelled elective cases 5.2. Seasonal reduction in bed availability (number of bed days lost due to increase in respiratory infection cases) 5.3. Number of episodes children with respiratory symptoms are transferred to or retrieved from other PICUs 6. Existing health care data (anonymised) using data codes (HES/PICANET/ICD and SNOMED codes) for respiratory infection in children under age 3 years at recruiting sites during the period of rec

—

Countries

England, United Kingdom

Contacts

Public ContactLauren McLellan

stoprsv@lstmed.ac.uk+44 (0)151 832 1719

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026