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The effect of exercise on brain blood flow and metabolism in stroke survivors

The effect of a fitness and mobility exercise programme on glucose control and blood flow in the brain in older adults with chronic stroke

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN41026907
Enrollment
42
Registered
2011-08-04
Start date
2011-01-01
Completion date
Unknown
Last updated
2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke Circulatory System Stroke

Interventions

1. A fitness and mobility exercise programme based upon the intervention protocol devised by Pang and colleagues (Pang et al., 2005b) 2. The exercise intervention lasts 19 weeks and participants will
Pang et al., 2005a
Eng JJ et al., 2003) 4. Previous studies have established very high levels of compliance with the programme, alongside post intervention improvements in fitness levels, paretic femoral bone mineral de
Pang et al., 2005b
Eng JJ et al., 2003) 5. Participants will wear a Polar heart rate monitor to assess if they are exercising within the set heart rate ranges required by the exercise protocol 6. The polar heart rate mo

Sponsors

Royal Victoria Infirmary, Newcastle (UK)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Over 50 years old 2. Diagnosed with a stroke by a stroke physician through computer tomography or magnetic resonance imaging and clinical characteristics at least six months previously 3. Participants are all able to walk for six minutes independently allowing for rests with or without a stick 4. Lives at home 5. Completed all conventional physiotherapy offered by the National Health Service (NHS)

Exclusion criteria

Exclusion criteria: 1. The absolute and relative contraindications to exercise testing as stated by the American Heart Association (Fletcher et al., 2001) 2. Other neurological or medical conditions in addition to stroke which would prevent individuals from participating 3. A diagnosis of diabetes, the presence of pain on walking (>5 on a visual analogue scale of pain) 4. Untreated major depression 5. Cognitive or speech problems limiting understanding of the study (participants were excluded if their Mini Mental Scale Examination (MMSE) was under 25 and if they were unable to follow two stage commands) (Folstein et al. 1975)

Design outcomes

Secondary

MeasureTime frame
1. Cardiorespiratory fitness 2. Body composition 3. Stroke impairment 4. Cognition 5. Endurance speed and balance 6. Physical activity 7. Quality of life

Primary

MeasureTime frame
1. Glucose control (frequently sampled oral glucose tolerance test) 2. Cerebral blood flow via magnetic resonance imaging (MRI)

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026