Effectivity of low-dose radon hyperthermia therapy on atopic dermatitis Skin and Connective Tissue Diseases Atopic dermatitis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Atopic Dermatitis, from chronic moderate to severe disease state. (mild: SCORAD 50) 2. Patient SCORAD value must be between 25 and 50 for inclusion 3. AD must be diagnosed and verified by a dermatologist 4. Age range 18 - 70 years 5. Signed Informed Consent must be obtained from each patient 6. Patients must be able to fill out a questionnaire by themselves
Exclusion criteria
Exclusion criteria: 1. Pregnancy or breast feeding period 2. Incompatibility of patients to treatment methods 3. Erosions, ulcers 4. Viral or bacterial superinfections 5. Severe internal diseases 6. Consumption of potential photosensitizers 7. Concomitant or past malignant skin tumors 8. Radon therapy or similar radiation (UV/light) treatment within the past year 9. Consumption of oral immunosuppressive drugs (within 6 months before entering the study) 10. Claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SCORAD (SCORing Atopic Dermatitis) questionnaire for specific assessment of skin condition in AD at before, directly after cure stay and 3, 6, and 9 months after the end of the cure stay. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured before, directly after cure stay, and three, six, and nine months after the end of the cure stay: 1. Quality of life (EQ-5D-5L) 2. Skin condition (SKINDEX-29) 3. Analysis of blood samples (MDC/CCL22, CTACK/CCL27, TARC/CCL17, IgE, IL-4, IL-13) | — |
Countries
Austria, Germany