Erectile dysfunction, peripheral vascular disease Circulatory System Peripheral vascular disease
Conditions
Interventions
Suitably screened and consenting patients will undertake an Exercise Tolerance Test (ETT) (modified Bruce protocol). Once baseline is established (two tests, 2 weeks apart), Tadalafil 10 mg daily or p
Sponsors
Guy's and St Thomas' NHS Foundation Trust (UK)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Male aged 40 - 80 years 2. Erectile dysfunction (Sexual Health Inventory for Men [SHIM] score less than 21) 3. Peripheral vascular disease (PVD) (confirmed by previous ultrasound studies)
Exclusion criteria
Exclusion criteria: 1. Contraindication to PDE 5 inhibitor 2. Inability to undertake an exercise tolerance test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total number of minutes/seconds on the exercise treadmill. Time to first report of leg pain will be recorded, measured at the end of weeks 3, 4 and 6 | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in score on the Walking Impairment Questionnaire and the Peripheral Artery Disease Symptom Scale, measured at the end of weeks 3, 4 and 6 | — |
Countries
United Kingdom
Outcome results
None listed