Imaging and quantification of myocardial scars in patients with acute or chronic myocardial infarction, inflammatory heart disease, or hypertrophic cardiomyopathy Circulatory System Acute myocardial infarction, other forms of chronic ischaemic heart disease, hypertrophic cardiomyopathy, myocarditis, unspecified
Conditions
Interventions
The routine MRI examination will be expanded to include the following sequences:
- T1-MOLLI- mapping short-axis images in breath-hold.
- T1-MOLLI mapping short-axis acq
Sponsors
Charité - University Medicine Berlin
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Written consent of the patient prior to commencement of study-specific actions 2. Capable of giving consent and capable of understanding the nature and scope of the clinical trial 3. Aged =18 years 4. Confirmed diagnosis or suspected diagnosis of acute or chronic myocardial infarction, inflammatory heart disease, or hypertrophic cardiomyopathy 5. Clinically indicated cardiac MRI examination with gadolinium-containing contrast agent according to the disease present
Exclusion criteria
Exclusion criteria: 1. Absolute contraindication to MRI examination (e.g. presence of metal implants, insulin pumps, pacemakers, ICDs, orbital foreign bodies, non-MRI cochlear implants, cerebral vascular clips) 2. Known allergy to MRI contrast media 3. Pregnant or breastfeeding 4. Have already participated in this study 5. Refusal to participate 6. Not capable of giving consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scar mass measured using a semi-automatic thresholding-based approach (full width at half maximum) at a single timepoint (the time the MRI image was taken) | — |
Secondary
| Measure | Time frame |
|---|---|
| Synthetic full-dose recording performance compared to the reference standard measured by the signal-to-noise ratio and contrast-to-noise ratio of the MRI image at the single timepoint | — |
Countries
Germany
Outcome results
None listed