Renovascular hypertension Circulatory System Hypertension
Conditions
Interventions
Added 25/02/2009: the study was terminated early due to recruitment issue.
Inclusion of patients presenting a controlled hypertension with 2 or 3 antihypertensive drugs and risk factors for renovas
Sponsors
Hospital Notre-Dame (Montréal) (Canada)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Hypertension greater than 140/90 mmHg with two hypertensive drugs 2. Hypertension less than 140/90 mmHg with three antihypertensive drugs 3. Aged greater than or equal to 30 years old, either sex 4. Atherosclerotic renal artery stenosis of more than 60% on catheter angiography or 70% on computed tomography (CT) or magnetic resonance (MR) angiography 5. Doppler resistive index less than 0.75
Exclusion criteria
Exclusion criteria: 1. Creatinine clearance less than 30 ml/min 2. Non controlled hypertension (greater than 160/105 mmHg) despite 3 anti-hypertensive drugs 3. Renal artery stenosis greater than 95% 4. Fibromuscular dysplasia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic and diastolic blood pressure 12 months post-randomisation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Blood pressure at 1 and 6 months post-randomisation 2. Clinical success on blood pressure control at 12 months 3. Serum creatine clearance when off antihypertensive drugs during 12 months? Does it mean that you have no control over those? 4. Morbidity related to cardiovascular events during follow-up 5. Incidence of renal artery restenosis | — |
Countries
Canada
Outcome results
None listed