Preterm intubations Pregnancy and Childbirth
Conditions
Interventions
All admitted neonates would be screened for study inclusion and exclusion criteria. For those infants who full fill the study criteria will be approached for prospective consent, whenever possible. Wh
Sponsors
South Tees Hospitals NHS Foundation Trust
Eligibility
Sex/Gender
All
Age
0 Weeks to 30 Weeks
Inclusion criteria
Inclusion criteria: 1. Birth gestational age < 30 weeks based on mother’s last menstrual period or best obstetric estimate with first trimester ultrasound 2. Need for semi/elective intubation in the neonatal unit and the need ascertained by the neonatal team
Exclusion criteria
Exclusion criteria: Current exclusion criteria as of 15/09/2025: 1. Perceived difficult airway by the medical team. 2. Previous intubation episode with more than two intubation attempts for successful intubation by an experienced intubators (Neonatal Consultant). 3. Contraindication to High Flow Nasal Cannula (e.g., congenital nasal anomaly, congenital diaphragmatic hernia, or abdominal wall defect). 4. Delivery room intubations. 5. Emergency intubations as ascertained by the clinical team (e.g. Heart rate <100/min, apnea at the time of procedure). 6. LISA/MIST technique of surfactant administration 7. Infants diagnosed with pneumothorax needing needle or chest tube drainage. 8. Infants with cyanotic heart disease. _____ Previous exclusion criteria: 1. Perceived difficult airway by the medical team. 2. Previous intubation episode with more than two intubation attempts for successful intubation. 3. Delivery room intubations. 4. Emergency intubations as ascertained by the clinical team (e.g. Heart rate < 100/min, apnea at the time of procedure). 5. LISA/MIST technique of surfactant administration 6. Infants diagnosed with pneumothorax needing needle or chest tube drainage. 7. Infants with cyanotic heart disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to oxygen desaturate defined as drop in oxygen saturation (Spo2) by 20% from baseline for duration of the intubation attempt | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Total number of intubation attempts before successfully placing the breathing tube 2. Severity of desaturation: Change in baseline oxygen saturation prior to the intubation procedure to lowest Spo2 value during the intubation procedure measured using continuous pulse oximetry 3. Lowest and highest oxygen saturation (Spo2) during the procedure measured using continuous pulse oximetry 4. Proportion of time Spo2 within the target range 90-95% measured using continuous pulse oximetry 5. Proportion of time Spo2 above 95% measured using continuous pulse oximetry 6. Proportion of time oxygen saturation below 80%: Time below Spo2 80%/ Total duration of intubation procedure measured using continuous pulse oximetry | — |
Countries
England, United Kingdom
Contacts
Public ContactPrakash Kannan Loganathan
Outcome results
None listed