Digestion and nutrient bioaccessibility Digestive System
Conditions
Interventions
Participants will eat on 5 separate occasions the test meals rich in either fat (Study 1) or starch (Study 2):
Study 1 (3 visits)
1. 85 g of whole almonds given with a muffin and some custard
2. A m
Sponsors
King's College London (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Male or female aged 20-60 years, who previously had proctocolectomy 2. Stable at least 12 months post-operative 3. Normal stoma functions (digest and excrete food without any difficulty)
Exclusion criteria
Exclusion criteria: 1. Allergy to almonds or related products, gluten and any other added ingredients in recipe of the test meal 2. Previous case of obstruction of the stoma 3. Body mass index 35 kg/m2 4. Have a diagnosed mouth, throat or gastrointestinal tract problem (other than ileostomy) that may affect normal ingestion and digestion of food 5. Plasma glucose > 7 mmol/L 6. Plasma cholesterol > 7.8 mmol/L 7. Plasma triacylglycerol > 3 mmol/L 8. On a medication regimen that would invalidate the results as judged by the medical advisor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Indicative measure of the digestibility (nutrient loss and modification in cell wall structure) of fat or starch foods during passage throught the upper gastrointestinal tract | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Measuring the glycaemic and lipaemic response to the test meals including insulin and c-peptide 2. Measuring the particle size of chewed and digested samples 3. Examination of the microstructure of chewed and digested samples 4. Measuring gut hormones [peptide YY (PYY), cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP)] For Study 1, plasma triacylglycerol concentrations will be measured hourly up to 8 h to determine the overall level of lipaemia after eating the test meal. Plasma glucose and insulin will also be measured at 0, 15, 30, 45, 60, 90, and 120 min and thereafter at 3, 4, 5, 6, 7, and 8 h. For Study 1 and 2, plasma glucose and insulin concentrations will be measured at 0, 15, 30, 45, 60, 90, 120, 150 min and at hourly intervals up to 4 h, to determine blood glucose and insulin levels after eating the test meal. | — |
Countries
United Kingdom
Outcome results
None listed