Treatment reversible and irreversible pulpitis in mature permanent teeth Oral Health
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. A mature permanent tooth indicated for extraction for orthodontic reasons that does not have any carious lesions for the reversible pulpitis groups 2. Mature permanent tooth requiring extraction (such as third molars) has deep carious lesions with clinical signs and symptoms of irreversible pulpitis (spontaneous or intermittent acute pain) for irreversible pulpitis groups 3. A positive response to pulp sensitivity tests with no signs of pulp necrosis (such as edema, fistula or severe sensitivity to percussion) 4. Restorable tooth without the need for a crown or posts, the gingival sulcus depth between 1-3 mm, and normal tooth mobility 5. The periapical radiograph showed a pulp chamber with relatively normal dimensions without degenerative activity (pulp stones, calcification, severe canal narrowing in the vertical direction) 6. Absence of periapical and furcation radiolucency 7. Absence of internal or external absorption
Exclusion criteria
Exclusion criteria: 1. History of immune or bleeding diseases 2. Medications that may affect the metabolism 3. Uncontrolled pulp hemorrhage after pulpotomy procedures within 10 minutes of hemostasis 4. Abnormal color and appearance of the pulp tissue 5. Absence of hemorrhage or little hemorrhage in a dark red color after pulp exposure or after pulpotomy procedures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The severity of inflammation was measured using histology after a week and 3 months by examining inflammatory cells, and the severity of inflammation was classified as follows: score 0: There are no inflammatory cells at or adjacent to the site of exposure, score 1: slight inflammation; presence of a small number of inflammatory cells, score 2: moderate inflammation medium number of inflammatory cells, score 3: Acute inflammation; abundant presence of inflammatory cells. | — |
Secondary
| Measure | Time frame |
|---|---|
| The expression of the inflammatory immune marker was measured after a week and 3 months using the amputation materials used according to the following index: score 0: no inflammation (no staining), score 1: mild inflammation (mild staining), score 2: moderate inflammation (moderate staining), score 3: severe inflammation (severe staining) | — |
Countries
Syria