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Application of melatonin (sleep hormone) gel in close proximity to the tooth with gum disease

Evaluation of melatonin gel as local drug delivery system for the treatment of periodontitis: a randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN40460432
Enrollment
44
Registered
2024-10-22
Start date
2020-10-20
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Management of stage I to stage III periodontitis in adults Oral Health

Interventions

Patients with chronic periodontitis were randomly assigned to the test and control groups using computer-generated random numbers following the completion of screening assessments. The test group used

Sponsors

College of Dental Science
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients with an age group between 20 and 45 years 2. The selected patients should have mild to moderate periodontal pockets (5-7 mm) clinically with radiographic evidence of bone loss, or periodontitis stage II (maximum probing depth =5 mm and radiographic bone loss of 15% to 33%, coronal third) and periodontitis stage III (probing pocket depth =6mm and radiographic bone loss extending to mid-third of root and be-yond) according to the 2017 World Workshop classification

Exclusion criteria

Exclusion criteria: 1. Suffering from systemic diseases such as migraine, insomnia, as well as smokers, alcoholics, pregnant, and lactating individuals 2. Individuals who had taken antibiotics or anti-inflammatory drugs within the past month were excluded from the study

Design outcomes

Primary

MeasureTime frame
1. Full mouth plaque score is measured using the plaque index at baseline, 1 month, and 3 months 2. Gingival inflammation is measured using the gingival index at baseline, 1 month, and 3 months 3. Gingival bleeding is measured using the gingival bleeding index at baseline, 1 month, and 3 months 4. Probing pocket depth (PPD) is measured using the UNC-15 probe at baseline, 1 month, and 3 months 5. Clinical attachment level (CAL) is measured using the UNC-15 probe at baseline, 1 month, and 3 months

Secondary

MeasureTime frame
Salivary Superoxide Dismutase (SOD) levels measured using spectrophotometry at baseline, 1 month, and 3 months

Countries

India

Contacts

Public ContactRashmi Srinath
rashmisriperio@yahoo.co.in+91 9739035346

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026