Study of patients with severe high blood pressure referred to hospital for same-day specialist review

Study of patients with severe hypertension referred to hospital for same-day specialist review

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN40430183

Enrollment

600

Registered

2020-10-05

Start date

2020-11-01

Completion date

Unknown

Last updated

2020-10-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension Circulatory System Hypertension

Interventions

The researchers aim to carry out an observational study comparing the natural history of individuals with severe hypertension referred for same-day specialist review with a control group of individual

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adults aged 18 and over 2. Severe hypertension (systolic >180 mmHg and/or diastolic >110 mmHg) 3. Referred for same-day specialist review (for cases only)

Exclusion criteria

Exclusion criteria: 1. Pre-existing renal replacement therapy 2. Acute stroke

Design outcomes

Primary

Measure	Time frame
A combined primary outcome of: 1. Stroke measured by review of electronic health records at 1, 2, 5 and 10 years 2. MI measured by review of electronic health records at 1, 2, 5 and 10 years 3. Change in eGFR measured by review of electronic health records at 1, 2, 5 and 10 years 4. Need for renal dialysis measured by review of electronic health records at 1, 2, 5 and 10 years 5. Mortality measured by review of electronic health records at 1, 2, 5 and 10 years	—

Measure

Time frame

A combined primary outcome of: 1. Stroke measured by review of electronic health records at 1, 2, 5 and 10 years 2. MI measured by review of electronic health records at 1, 2, 5 and 10 years 3. Change in eGFR measured by review of electronic health records at 1, 2, 5 and 10 years 4. Need for renal dialysis measured by review of electronic health records at 1, 2, 5 and 10 years 5. Mortality measured by review of electronic health records at 1, 2, 5 and 10 years

—

Secondary

Measure	Time frame
1. Rehospitalisation within 2 years, measured by review of electronic health records at 1, 2, 5 and 10 years 2. Diagnosis of accelerated hypertension within 10 years, measured by review of electronic health records at 1, 2, 5 and 10 years	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026