Studying the effect and safety of percutaneous endoscopy operation combined with platelet-rich plasma injection for treating lumbar disc herniation in young and middle-aged

Percutaneous endoscopic nucleotomy combined with platelet-rich plasma injection for treating lumbar disc herniation in young and middle-aged

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN40407546

Enrollment

Registered

2024-09-05

Start date

2022-04-01

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lumbar disc herniation Musculoskeletal Diseases

Interventions

From April 2022 to December 2023, 60 patients with LDH were randomly divided using the random number table method into two groups of 30 each. The observation group underwent percutaneous endoscopic nu

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age 18-55 years 2. Diagnosed with LDH, with significant radicular symptoms and positive straight leg raise test, unresponsive to 1 month of conservative treatment 3. Single-segment responsible for surgery

Exclusion criteria

Exclusion criteria: 1. Lumbar infection, tumors, or severe deformities, lumbar instability or spondylolisthesis 2. Blood system-related diseases 3. History of long-term treatment with NSAIDs or immunosuppressants before surgery 4. Significant calcification or bony stenosis of the responsible lumbar disc 5. Psychiatric disorders that prevent full cooperation with treatment

Design outcomes

Primary

Measure	Time frame
1. Pain intensity measured using the Visual Analogue Scale (VAS) preoperatively, 3 days postoperatively, 3 months postoperatively, and 6 months postoperatively 2. Degree of disability measured using the Oswestry Disability Index (ODI) preoperatively, 3 days postoperatively, 3 months postoperatively, and 6 months postoperatively 3. Clinical efficacy evaluated using the modified MacNab criteria for the excellent and good rate at the final follow-up	—

Measure

Time frame

1. Pain intensity measured using the Visual Analogue Scale (VAS) preoperatively, 3 days postoperatively, 3 months postoperatively, and 6 months postoperatively 2. Degree of disability measured using the Oswestry Disability Index (ODI) preoperatively, 3 days postoperatively, 3 months postoperatively, and 6 months postoperatively 3. Clinical efficacy evaluated using the modified MacNab criteria for the excellent and good rate at the final follow-up

—

Secondary

Measure	Time frame
1. Pfirrmann grading of the operated disc segment using MRI preoperatively and 6-9 months postoperatively 2. Incidence of complications recorded during follow-up	—

Countries

China

Contacts

Public ContactHairu Qi

qhr10363@163.com+86 (0)13549845311

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026