Short term effects of low caffeine energy drinks on blood vessel and heart functions in healthy volunteers

Acute effects of low caffeine energy drinks on endothelial and myocardial functions in healthy volunteers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN40313372

Enrollment

Registered

2021-10-19

Start date

2014-08-01

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Determining the effect of energy drink consumption on heart and blood vessel function in healthy volunteers Circulatory System

Interventions

The volunteers are assigned to study drinks through online randomization (randomizer.org) , they will be asked to drink 355 ml of one of the study drinks (commercially available energy drink containi

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy volunteers giving informed consent

Exclusion criteria

Exclusion criteria: 1. Any abnormalities in their baseline screening echocardiographic examination 2. Heavy caffeine consumers (>200 mg/day) 3. Smoke >5 cigarettes/day 4. Low BMI (30 kg/m²) 5. Acute infection

Design outcomes

Primary

Measure	Time frame
The change in endothelial flow mediated dilation (FMD) is measured before and 60 minutes after energy drink consumption.	—

Secondary

Measure	Time frame
The change in myocardial strain levels is measured using Echocardiographic images for 2 dimensional speckle tracking echocardiography of left and right ventricles recorded before and 60 minutes after study drink consumption, which are then analyzed offline by an investigator blind to patient data.	—

Countries

Turkey

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026