Serotonin transporter gene as predictor of recovery after surgery

Serotonin transporter gene polymorphisms as a predictor of recovery after laporoscopic cholecystectomy: a non-randomised interventional screening trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN40219584

Enrollment

250

Registered

2010-04-29

Start date

2008-01-01

Completion date

Unknown

Last updated

2018-03-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Mental Health Research Network

Interventions

1. Buccal swab - taken before the operation an analysed for the serotonin gene length polymorphism only 2. Questionnaires - filled in by participants before the operation and 6 weeks after: 2.1. 36-it

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective laparoscopic cholecystectomy 2. Male and female, aged 18 - 65 years

Exclusion criteria

Exclusion criteria: Patients undergoing open laporoscopic cholecystectomy

Design outcomes

Primary

Measure	Time frame
Change in score on the Beck Depression Inventory (BDI), scored on a scale of 0 - 63, measured on day before operation and 6 weeks after.	—

Secondary

Measure	Time frame
1. Change in scores on Health Anxiety and Depression (HAD) questionnaire, Chalder's Fatigue Scale, Eysenck Personality Questionnaire - Revised and 36-item short form health survey (SF-36), measured on day before operation and 6 weeks after 2. Visual Analogue Scale (VAS), measured day after operation and 6 weeks after 3. Unvalidated questionnaire to assess current health, measured before operation 4. Unvalidated questionnaire to assess common post-operative milestones, measured 6 weeks after operation	—

Measure

Time frame

1. Change in scores on Health Anxiety and Depression (HAD) questionnaire, Chalder's Fatigue Scale, Eysenck Personality Questionnaire - Revised and 36-item short form health survey (SF-36), measured on day before operation and 6 weeks after 2. Visual Analogue Scale (VAS), measured day after operation and 6 weeks after 3. Unvalidated questionnaire to assess current health, measured before operation 4. Unvalidated questionnaire to assess common post-operative milestones, measured 6 weeks after operation

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 1, 2026