Hyperemesis gravidarum Pregnancy and Childbirth Hyperemesis gravidarum
Conditions
Interventions
Participants will be randomized into two arms (1:1) via labeled envelopes which will be given to the participants upon recruitment. Randomization will be generated by a random sequence generator, prov
Sponsors
University of Malaya Medical Centre
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Aged =18 years 2. Confirmed pregnancy by urine pregnancy test and presence of intrauterine sac 3. Clinical diagnosis of hyperemesis gravidarum, with presence of ketonuria of at least 2+ on admission 4. Gestation age less than 14 weeks 5. First hospital admission for hyperemesis gravidarum, and within 2 h of admission, where rehydration therapy has not formally been commenced
Exclusion criteria
Exclusion criteria: 1. Allergy to oral rehydration salts 2. Women with an underlying medical disorder (including diabetes mellitus, hypertension, heart disease, renal disease, and endocrine disorder such as hyperthyroid disorder) 3. Multiple pregnancy 4. Proven non viable pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Current primary outcome measure as of 22/07/2021: 1. Patients satisfaction with allocated rehydration regime using VNRS scale (Visual Numerating Rating Score) from 0 to 10, with 0 being the worst score) at 12 h 2. Weight (g) measured at baseline and 12 h 3. Improvement of ketonuria measured using urine samples collected at baseline and 12 h Previous primary outcome measure: 1. Patients satisfaction with allocated rehydration regime using VNRS scale (Visual Numerating Rating Score) from 0 to 10, with 0 being the worst score) at 12 h 2. Weight (g) measured at baseline and 12 h 3. Improvement of ketonuria measured using blood samples collected at baseline and 12 h | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Hospital admission to discharge interval measured at the point of discharge 2. Nausea measured using serial nausea score at 0, 4, 8, and 12 h 3. Treatment preference measured using Likert’s scale on the preference of treatment at 12 h 4. Deviation from protocol measured from investigators notes at the point of discharge 5. Hematocrit (Hct), electrolytes level measured using blood samples collected at 12 h | — |
Countries
Malaysia
Contacts
Public ContactWan Nurul Ezyani Wan Jabarudin
Outcome results
None listed