Healthy volunteer bronchoscopy study

Bronchoalveolar lavage and biopsy findings in healthy non-smoking individuals

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN40147207

Enrollment

Registered

2012-01-25

Start date

2007-05-01

Completion date

Unknown

Last updated

2020-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic cough Signs and Symptoms Cough

Interventions

1. Blood test 2. Pulmonary funciton test 3. Skin prick allergy test 4. Methacholine challenge (bronchial hyper-reactivity test) 24 hours

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Over 18 years of age 2. Normal lung function 3. Negative methacholine challenge (no bronchial hyper-reactivity)

Exclusion criteria

Exclusion criteria: 1. Recent upper respiratory infection (10 pack/year history 10. History of anaphylaxis or known allergy to lignocaine/midazolam/methacholine

Design outcomes

Primary

Measure	Time frame
Presence or absence of airway inflammation in healthy volunteers	—

Secondary

Measure	Time frame
1. Lymphocyte count in healthy volunteers of different ages/sex 2. Presence/absence of pepsin in lavage of healthy volunteers 3. Airway wall histology in healthy volunteers 4. Evidence of allergy (Immunoglobulins) 5. Provision of a bank of biopsy and lavage samples from healthy volunteers for use in future research into airway wall remodelling	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 25, 2026